Source:http://linkedlifedata.com/resource/pubmed/id/12565932
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2003-2-4
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pubmed:abstractText |
The synthesis of optically pure long-chain 2-amino-alcohols and 1-O-dodecyl-2-deoxy-2-amino-sn-glycerol was carried out starting from L- or D-Boc-Ser(OBn)-ol by oxidation and consecutive Wittig reaction or etherification reaction. 2-Amino-oleyl alcohol was synthesized by reduction of the corresponding 2-amino-oleic acid. All the long chain amino-alcohols presented interesting inhibition of carrageenin-induced paw edema in rats (ED(50) from 0.017 to 0.010 mmol/kg).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-894X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
375-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12565932-Amino Alcohols,
pubmed-meshheading:12565932-Animals,
pubmed-meshheading:12565932-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:12565932-Carrageenan,
pubmed-meshheading:12565932-Edema,
pubmed-meshheading:12565932-Female,
pubmed-meshheading:12565932-Indicators and Reagents,
pubmed-meshheading:12565932-Oxidation-Reduction,
pubmed-meshheading:12565932-Pain Measurement,
pubmed-meshheading:12565932-Rats,
pubmed-meshheading:12565932-Rats, Inbred F344
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pubmed:year |
2003
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pubmed:articleTitle |
Synthesis and In vivo anti-inflammatory activity of long-chain 2-amino-alcohols.
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pubmed:affiliation |
.Chemical Laboratories, Agricultural University of Athens, Iera Odos 75, 118 55 Athens, Greece.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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