Linked Life Data

12565790

Source:http://linkedlifedata.com/resource/pubmed/id/12565790

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-2-5
pubmed:abstractText
Mononuclear cell infiltration of the thyroid is a prominent feature of chronic lymphocytic thyroiditis. Adhesion molecules play a major role in determining the localization of inflammatory mononuclear cells in the thyroid. Previous reports from animal models and human studies have described the thyroidal expression of adhesion molecules only late in clinical disease. In this study, we examined the distribution and kinetics of expression of E-selectin, VCAM-1, LFA-1, and ICAM-1 in the NOD-H2h4 mouse, a model of spontaneous autoimmune thyroiditis accelerated by dietary iodine. Mice were fed 0.015% NaI in their drinking water for 2, 4, 6, 8, and 16 weeks, and thyroids were removed, serially sectioned, and stained in an avidin-biotin-peroxidase assay. We found a dramatic increase in E-selectin and VCAM-1 expression on intrathyroidal endothelial cells after 16 weeks of iodine treatment. In addition, we describe for the first time that thyrocytes from the NOD-H2h4 mouse, and the parental NOD, constitutively express ICAM-1 independent of iodine treatment and prior to mononuclear cell infiltration of the thyroid gland. ICAM-1 was not detected on the thyrocytes of other untreated strains of mice, implicating expression of this adhesion molecule as a critical event in the recruitment of inflammatory mononuclear cells to the thyroid.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0014-4800
pubmed:author
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
155-63
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:12565790-Animals, pubmed-meshheading:12565790-Disease Models, Animal, pubmed-meshheading:12565790-Disease Susceptibility, pubmed-meshheading:12565790-E-Selectin, pubmed-meshheading:12565790-Female, pubmed-meshheading:12565790-Humans, pubmed-meshheading:12565790-Immunohistochemistry, pubmed-meshheading:12565790-Intercellular Adhesion Molecule-1, pubmed-meshheading:12565790-Leukocytes, Mononuclear, pubmed-meshheading:12565790-Lymphocyte Function-Associated Antigen-1, pubmed-meshheading:12565790-Male, pubmed-meshheading:12565790-Mice, pubmed-meshheading:12565790-Mice, Inbred NOD, pubmed-meshheading:12565790-Sodium Iodide, pubmed-meshheading:12565790-Thyroid Gland, pubmed-meshheading:12565790-Thyroiditis, Autoimmune, pubmed-meshheading:12565790-Vascular Cell Adhesion Molecule-1
pubmed:year
2002
pubmed:articleTitle
Adhesion molecules as susceptibility factors in spontaneous autoimmune thyroiditis in the NOD-H2h4 mouse.
pubmed:affiliation
Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.