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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-2-4
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pubmed:abstractText |
Tritium-labelled dihydro derivatives of the cyanobacterial peptide hepatotoxin nodularin were prepared by reduction with sodium boro[3H]hydride. The optimised reaction gave two dihydronodularin stereoisomers which were purified by high-performance liquid chromatography with a mobile phase of methanol-0.7% sodium sulfate (6:4) and a C(18) stationary phase. The specific activities of the stereoisomers were 1780-1807 dis min(-1) ng(-1). The radiolabelled dihydronodularins were tested for stability and used for toxicokinetic studies in mice. Liver was the main site of toxin accumulation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0041-0101
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
153-62
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12565734-Animals,
pubmed-meshheading:12565734-Chromatography, High Pressure Liquid,
pubmed-meshheading:12565734-Cyanobacteria,
pubmed-meshheading:12565734-Drug-Induced Liver Injury,
pubmed-meshheading:12565734-Female,
pubmed-meshheading:12565734-Isotope Labeling,
pubmed-meshheading:12565734-Liver,
pubmed-meshheading:12565734-Marine Toxins,
pubmed-meshheading:12565734-Mice,
pubmed-meshheading:12565734-Mice, Inbred BALB C,
pubmed-meshheading:12565734-Peptides, Cyclic,
pubmed-meshheading:12565734-Stereoisomerism,
pubmed-meshheading:12565734-Tritium
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pubmed:year |
2003
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pubmed:articleTitle |
Synthesis and organotropism of 3H-dihydro derivatives of the cyanobacterial peptide hepatotoxin nodularin.
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pubmed:affiliation |
Department of Biochemistry and Pharmacy, Abo Akademi University, P.O. Box 66, 20521, Turku, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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