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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-3-13
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pubmed:abstractText |
Antidepressant efficacy of selective serotonin reuptake inhibitors (SSRIs) has been shown to depend on functional polymorphisms within the promoter region of the serotonin transporter gene (5-HTTLPR). This gene gives rise to a biallelic polymorphism designated long (l) and short (s). Homozygosity for the long variant (ll-genotype) is associated with a two times more efficient 5-HT uptake compared to the s/l- or s/s-genotype. Paired pulse transcranial magnetic stimulation is a feasible tool in detecting changes of motor cortex excitability induced by SSRIs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0033-3158
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
166
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
294-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12563545-Adult,
pubmed-meshheading:12563545-Alleles,
pubmed-meshheading:12563545-Carrier Proteins,
pubmed-meshheading:12563545-Citalopram,
pubmed-meshheading:12563545-Electrophysiology,
pubmed-meshheading:12563545-Genotype,
pubmed-meshheading:12563545-Humans,
pubmed-meshheading:12563545-Magnetic Resonance Imaging,
pubmed-meshheading:12563545-Membrane Glycoproteins,
pubmed-meshheading:12563545-Membrane Transport Proteins,
pubmed-meshheading:12563545-Motor Cortex,
pubmed-meshheading:12563545-Nerve Tissue Proteins,
pubmed-meshheading:12563545-Nervous System,
pubmed-meshheading:12563545-Polymorphism, Genetic,
pubmed-meshheading:12563545-Promoter Regions, Genetic,
pubmed-meshheading:12563545-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:12563545-Serotonin Uptake Inhibitors,
pubmed-meshheading:12563545-Startle Reaction
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pubmed:year |
2003
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pubmed:articleTitle |
Allelic variation in the serotonin transporter promoter affects neuromodulatory effects of a selective serotonin transporter reuptake inhibitor (SSRI).
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pubmed:affiliation |
Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstrasse 84, 93053, Regensburg, Germany. peter.eichhammer@bzk.uni-regensburg.de
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pubmed:publicationType |
Journal Article,
Comparative Study
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