| pubmed-article:12563315 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12563315 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:12563315 | lifeskim:mentions | umls-concept:C0027996 | lld:lifeskim |
| pubmed-article:12563315 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:12563315 | lifeskim:mentions | umls-concept:C1539603 | lld:lifeskim |
| pubmed-article:12563315 | lifeskim:mentions | umls-concept:C1333902 | lld:lifeskim |
| pubmed-article:12563315 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:12563315 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12563315 | pubmed:dateCreated | 2003-3-3 | lld:pubmed |
| pubmed-article:12563315 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12563315 | pubmed:abstractText | Nicotinic acid (niacin), a vitamin of the B complex, has been used for almost 50 years as a lipid-lowering drug. The pharmacological effect of nicotinic acid requires doses that are much higher than those provided by a normal diet. Its primary action is to decrease lipolysis in adipose tissue by inhibiting hormone-sensitive triglyceride lipase. This anti-lipolytic effect of nicotinic acid involves the inhibition of cyclic adenosine monophosphate (cAMP) accumulation in adipose tissue through a G(i)-protein-mediated inhibition of adenylyl cyclase. A G-protein-coupled receptor for nicotinic acid has been proposed in adipocytes. Here, we show that the orphan G-protein-coupled receptor, 'protein upregulated in macrophages by interferon-gamma' (mouse PUMA-G, human HM74), is highly expressed in adipose tissue and is a nicotinic acid receptor. Binding of nicotinic acid to PUMA-G or HM74 results in a G(i)-mediated decrease in cAMP levels. In mice lacking PUMA-G, the nicotinic acid-induced decrease in free fatty acid (FFA) and triglyceride plasma levels was abrogated, indicating that PUMA-G mediates the anti-lipolytic and lipid-lowering effects of nicotinic acid in vivo. The identification of the nicotinic acid receptor may be useful in the development of new drugs to treat dyslipidemia. | lld:pubmed |
| pubmed-article:12563315 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12563315 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12563315 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12563315 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12563315 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12563315 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12563315 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12563315 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12563315 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:12563315 | pubmed:issn | 1078-8956 | lld:pubmed |
| pubmed-article:12563315 | pubmed:author | pubmed-author:PfefferKlausK | lld:pubmed |
| pubmed-article:12563315 | pubmed:author | pubmed-author:KeroJukkaJ | lld:pubmed |
| pubmed-article:12563315 | pubmed:author | pubmed-author:OffermannsSte... | lld:pubmed |
| pubmed-article:12563315 | pubmed:author | pubmed-author:SchaubAnnette... | lld:pubmed |
| pubmed-article:12563315 | pubmed:author | pubmed-author:BlaukatAndree... | lld:pubmed |
| pubmed-article:12563315 | pubmed:author | pubmed-author:TunaruSorinS | lld:pubmed |
| pubmed-article:12563315 | pubmed:author | pubmed-author:WufkaChristia... | lld:pubmed |
| pubmed-article:12563315 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12563315 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:12563315 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12563315 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12563315 | pubmed:pagination | 352-5 | lld:pubmed |
| pubmed-article:12563315 | pubmed:dateRevised | 2011-11-3 | lld:pubmed |
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| pubmed-article:12563315 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12563315 | pubmed:articleTitle | PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. | lld:pubmed |
| pubmed-article:12563315 | pubmed:affiliation | Institute of Pharmacology, University of Heidelberg, Heidelberg, Germany. | lld:pubmed |
| pubmed-article:12563315 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12563315 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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