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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-3-3
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pubmed:databankReference |
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pubmed:abstractText |
Nicotinic acid (niacin), a vitamin of the B complex, has been used for almost 50 years as a lipid-lowering drug. The pharmacological effect of nicotinic acid requires doses that are much higher than those provided by a normal diet. Its primary action is to decrease lipolysis in adipose tissue by inhibiting hormone-sensitive triglyceride lipase. This anti-lipolytic effect of nicotinic acid involves the inhibition of cyclic adenosine monophosphate (cAMP) accumulation in adipose tissue through a G(i)-protein-mediated inhibition of adenylyl cyclase. A G-protein-coupled receptor for nicotinic acid has been proposed in adipocytes. Here, we show that the orphan G-protein-coupled receptor, 'protein upregulated in macrophages by interferon-gamma' (mouse PUMA-G, human HM74), is highly expressed in adipose tissue and is a nicotinic acid receptor. Binding of nicotinic acid to PUMA-G or HM74 results in a G(i)-mediated decrease in cAMP levels. In mice lacking PUMA-G, the nicotinic acid-induced decrease in free fatty acid (FFA) and triglyceride plasma levels was abrogated, indicating that PUMA-G mediates the anti-lipolytic and lipid-lowering effects of nicotinic acid in vivo. The identification of the nicotinic acid receptor may be useful in the development of new drugs to treat dyslipidemia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Nonesterified,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hypolipidemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Niacin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Nicotinic,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1078-8956
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
352-5
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pubmed:dateRevised |
2011-11-3
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pubmed:meshHeading |
pubmed-meshheading:12563315-Adipose Tissue,
pubmed-meshheading:12563315-Animals,
pubmed-meshheading:12563315-Cell Line,
pubmed-meshheading:12563315-Cloning, Molecular,
pubmed-meshheading:12563315-Fatty Acids, Nonesterified,
pubmed-meshheading:12563315-GTP-Binding Proteins,
pubmed-meshheading:12563315-Genes, Reporter,
pubmed-meshheading:12563315-Humans,
pubmed-meshheading:12563315-Hypolipidemic Agents,
pubmed-meshheading:12563315-Mice,
pubmed-meshheading:12563315-Mice, Knockout,
pubmed-meshheading:12563315-Molecular Sequence Data,
pubmed-meshheading:12563315-Niacin,
pubmed-meshheading:12563315-Radioligand Assay,
pubmed-meshheading:12563315-Receptors, Cell Surface,
pubmed-meshheading:12563315-Receptors, G-Protein-Coupled,
pubmed-meshheading:12563315-Receptors, Nicotinic,
pubmed-meshheading:12563315-Tissue Distribution,
pubmed-meshheading:12563315-Triglycerides
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pubmed:year |
2003
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pubmed:articleTitle |
PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect.
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pubmed:affiliation |
Institute of Pharmacology, University of Heidelberg, Heidelberg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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