| pubmed-article:12563261 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12563261 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:12563261 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:12563261 | lifeskim:mentions | umls-concept:C0033681 | lld:lifeskim |
| pubmed-article:12563261 | lifeskim:mentions | umls-concept:C0815089 | lld:lifeskim |
| pubmed-article:12563261 | lifeskim:mentions | umls-concept:C1523116 | lld:lifeskim |
| pubmed-article:12563261 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:12563261 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12563261 | pubmed:dateCreated | 2003-2-26 | lld:pubmed |
| pubmed-article:12563261 | pubmed:abstractText | The nature of signals that govern the development of immunoglobulin heavy chain-dependent B cells is largely unknown. Using mice deficient for the B cell-expressed Src-family protein tyrosine kinases (SFKs) Blk, Fyn and Lyn, we show an essential role of these kinases in pre-B cell receptor (pre-BCR)- mediated NF-kappaB activation and B cell development. This signaling defect is SFK specific, as a deficiency in Syk, which controls pre-B cell development, does not affect NF-kappaB induction. Impaired NF-kappaB induction was overcome by the activation of protein kinase C (PKC)-lambda, thus suggesting the involvement of PKC-lambda in pre-BCR-mediated SFK-dependent activation of NF-kappaB. Our data show the existence of a functionally distinct SFK signaling module responsible for pre-BCR-mediated NF-kappaB activation and B cell development. | lld:pubmed |
| pubmed-article:12563261 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12563261 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12563261 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12563261 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12563261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12563261 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12563261 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:12563261 | pubmed:issn | 1529-2908 | lld:pubmed |
| pubmed-article:12563261 | pubmed:author | pubmed-author:TarakhovskyAl... | lld:pubmed |
| pubmed-article:12563261 | pubmed:author | pubmed-author:RethMichaelM | lld:pubmed |
| pubmed-article:12563261 | pubmed:author | pubmed-author:LowellCliffor... | lld:pubmed |
| pubmed-article:12563261 | pubmed:author | pubmed-author:KarasuyamaHaj... | lld:pubmed |
| pubmed-article:12563261 | pubmed:author | pubmed-author:SaijoKaoruK | lld:pubmed |
| pubmed-article:12563261 | pubmed:author | pubmed-author:SantanaAngela... | lld:pubmed |
| pubmed-article:12563261 | pubmed:author | pubmed-author:SchmedtChrist... | lld:pubmed |
| pubmed-article:12563261 | pubmed:author | pubmed-author:AdachiTakahir... | lld:pubmed |
| pubmed-article:12563261 | pubmed:author | pubmed-author:SuI-HsinIH | lld:pubmed |
| pubmed-article:12563261 | pubmed:author | pubmed-author:PatkeAlinaA | lld:pubmed |
| pubmed-article:12563261 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12563261 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:12563261 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12563261 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12563261 | pubmed:pagination | 274-9 | lld:pubmed |
| pubmed-article:12563261 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12563261 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12563261 | pubmed:articleTitle | Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. | lld:pubmed |
| pubmed-article:12563261 | pubmed:affiliation | Laboratory of Lymphocyte Signaling, The Rockefeller University, New York, NY 10021, USA. saijok@mail.rockefeller.edu | lld:pubmed |
| pubmed-article:12563261 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12563261 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12563261 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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