Source:http://linkedlifedata.com/resource/pubmed/id/12563261
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2003-2-26
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pubmed:abstractText |
The nature of signals that govern the development of immunoglobulin heavy chain-dependent B cells is largely unknown. Using mice deficient for the B cell-expressed Src-family protein tyrosine kinases (SFKs) Blk, Fyn and Lyn, we show an essential role of these kinases in pre-B cell receptor (pre-BCR)- mediated NF-kappaB activation and B cell development. This signaling defect is SFK specific, as a deficiency in Syk, which controls pre-B cell development, does not affect NF-kappaB induction. Impaired NF-kappaB induction was overcome by the activation of protein kinase C (PKC)-lambda, thus suggesting the involvement of PKC-lambda in pre-BCR-mediated SFK-dependent activation of NF-kappaB. Our data show the existence of a functionally distinct SFK signaling module responsible for pre-BCR-mediated NF-kappaB activation and B cell development.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1529-2908
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pubmed:author |
pubmed-author:AdachiTakahiroT,
pubmed-author:KarasuyamaHajimeH,
pubmed-author:LowellClifford ACA,
pubmed-author:PatkeAlinaA,
pubmed-author:RethMichaelM,
pubmed-author:SaijoKaoruK,
pubmed-author:SantanaAngelaA,
pubmed-author:SchmedtChristianC,
pubmed-author:SuI-HsinIH,
pubmed-author:TarakhovskyAlexanderA
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
274-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading | |
pubmed:year |
2003
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pubmed:articleTitle |
Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development.
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pubmed:affiliation |
Laboratory of Lymphocyte Signaling, The Rockefeller University, New York, NY 10021, USA. saijok@mail.rockefeller.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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