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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-2-3
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pubmed:abstractText |
Cytotoxic T cells play an important role in graft-versus-host-disease (GvHD) and graft-versus-leukaemia/myeloma, which may occur in patients treated with an allogeneic stem cell transplantation (ASCT). Here, we describe the selection of a myeloma reactive CD4+ cytotoxic T cell-line (CTL) and two CD4+ clones from this CTL. The CTL was generated from the blood from a patient with multiple myeloma (MM) with graft versus myeloma/GvHD, following an ASCT. The CTL was stimulated using irradiated peripheral blood mononuclear cells and EBV transformed B cells from the myeloma patient (EBVp), both of which were obtained prior to ASCT. Both the CTL and the two T cell clones specifically lysed EBVp and secreted IFN-gamma after coculture with EBVp and autologous myeloma tumour cells in a class II restricted fashion. These results show that myeloma tumour cells and autologous B cells present a common polymorphic peptide that functions as a target for graft derived cytotoxic T cells. Identification of these proteins will give insight into the relationship between graft versus myeloma (GvM) and GvHD and may provide immunotherapeutical targets in the treatment of MM.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-10100574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-10100725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-10197809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-10384156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-10397734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-10438702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-10552958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-10636695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-10944138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-11964294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-1380540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-1402674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-1533591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-1536963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-1912589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-1967432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-2265242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-2297567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-2930922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-6088089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-7528862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-7581111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-7670118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-7723498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-8111046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-8329711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-8445426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-8532022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-8562947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-8622337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-8729449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-8992968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-9292530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-9354693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-9373199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-9450806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-9461441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-9490709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-9573003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-9780247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-9823960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562398-9989486
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
340-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12562398-Antigens, Surface,
pubmed-meshheading:12562398-B-Lymphocytes,
pubmed-meshheading:12562398-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12562398-Cell Line,
pubmed-meshheading:12562398-Cell Transformation, Viral,
pubmed-meshheading:12562398-Graft vs Host Reaction,
pubmed-meshheading:12562398-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:12562398-Herpesvirus 4, Human,
pubmed-meshheading:12562398-Humans,
pubmed-meshheading:12562398-Interferon-gamma,
pubmed-meshheading:12562398-Lymphocyte Activation,
pubmed-meshheading:12562398-Male,
pubmed-meshheading:12562398-Middle Aged,
pubmed-meshheading:12562398-Multiple Myeloma,
pubmed-meshheading:12562398-Plasma Cells
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pubmed:year |
2003
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pubmed:articleTitle |
Antigens shared by malignant plasma cells and normal B cells may be involved in graft versus myeloma.
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pubmed:affiliation |
Department of Haematology, UMCU, Utrecht, The Netherlands.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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