Linked Life Data

12561621

Source:http://linkedlifedata.com/resource/pubmed/id/12561621

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2003-2-3
pubmed:abstractText
In order to study the relationship between mutation of beta 3-adrenergic-receptor gene and the response to dietary intervention in obese children, 47 obese children were randomly separated into two groups. One was dietary intervention group(36 subjects); the other was control group(11 subjects). The subjects were investigated by dietary survey and anthropometry before and after dietary intervention carried out for 3 months. The mutation of beta 3-adrenergic receptor gene resulting from the replacement of tryptophan by arginine at position 64(Trp64Arg) in encoding amino acid residues was detected by using a polymerase chain reaction-restriction fragment length polymorphisms. The results showed that dietary fat was higher (40.7% of energy from fat) in the obese children. After dietary intervention, the increase of weight(kg) and BMI(kg/m2) were significantly lower in the obese children without mutation than in control group(P < 0.05), but the changes of weight and BMI in the obese children with mutations were similar to those of control group. It was concluded that the Trp64Arg mutation of beta 3-adrenergic receptor gene might be one of the reasons why the effect of dietary intervention was poor in some obese children.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1000-8020
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
359-61
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
[Mutation of beta 3-adrenergic-receptor gene and the response to dietary intervention in obese children].
pubmed:affiliation
Institute of Child and Adolescent Health, Peking University, Beijing 100083, China.
pubmed:publicationType
Journal Article, Clinical Trial, English Abstract, Randomized Controlled Trial