Linked Life Data

12561236

Source:http://linkedlifedata.com/resource/pubmed/id/12561236

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2003-2-3
pubmed:abstractText
Recently novel leads for histamine H3 receptor antagonists of the non-imidazole type have been described. As a continuation of this research eleven new carbamate derivatives possessing an additional ether functionality were prepared. The compounds were evaluated in vitro for their antagonist activity on isolated organs of guinea-pig (GP) H3 as well as H2, H1, and M3 receptors, respectively. All compounds investigated possessed moderate antagonist affinities at guinea-pig histamine H3 receptors (pA2 6.11-6.76). An ether functionality introduced in different places of the lipophilic part of carbamates differently influenced activity and selectivity toward H3, M3, and other histamine receptors tested.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0031-7144
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
791-5
pubmed:dateRevised
2007-1-29
pubmed:meshHeading
pubmed-meshheading:12561236-Animals, pubmed-meshheading:12561236-Carbamates, pubmed-meshheading:12561236-Electric Stimulation, pubmed-meshheading:12561236-Ethers, pubmed-meshheading:12561236-Guinea Pigs, pubmed-meshheading:12561236-Histamine Antagonists, pubmed-meshheading:12561236-Histamine H1 Antagonists, pubmed-meshheading:12561236-Histamine H2 Antagonists, pubmed-meshheading:12561236-Ileum, pubmed-meshheading:12561236-Magnetic Resonance Spectroscopy, pubmed-meshheading:12561236-Muscle, Smooth, pubmed-meshheading:12561236-Muscle Contraction, pubmed-meshheading:12561236-Piperidines, pubmed-meshheading:12561236-Receptor, Muscarinic M3, pubmed-meshheading:12561236-Receptors, Histamine H3, pubmed-meshheading:12561236-Receptors, Muscarinic, pubmed-meshheading:12561236-Structure-Activity Relationship
pubmed:year
2002
pubmed:articleTitle
Piperidine-containing histamine H3 receptor antagonists of the carbamate series: the influence of the additional ether functionality.
pubmed:affiliation
Department of Chemical Technology of Drugs, Medical College, Jagiellonian University, Kraków, Poland.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't