rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
11-12
|
pubmed:dateCreated |
2003-1-31
|
pubmed:abstractText |
Sixty healthy nonresponders were randomized to receive intramuscular (IM) high dose hepatitis B virus (HBV) vaccine versus IM standard dose HBV vaccine plus granulocyte-macrophage colony-stimulating factor (GM-CSF) at 0-2 months. Antibody to hepatitis B surface antigen was measured 1 month after each dose and 3 months after the last dose. Two regimens were equivalent in eliciting seroprotection in nonresponders. Weight-height index (WHI) <39 and alanine transaminase (ALT) <39 mg/dl predicted which nonresponders would seroconvert. A three-dose regimen of standard dose HBV vaccine plus GM-CSF may be a useful for seroprotection of healthy nonresponders.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0264-410X
|
pubmed:author |
|
pubmed:copyrightInfo |
Copyright 2002 Elsevier Science Ltd.
|
pubmed:issnType |
Print
|
pubmed:day |
7
|
pubmed:volume |
21
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1174-9
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:12559795-Adjuvants, Immunologic,
pubmed-meshheading:12559795-Adolescent,
pubmed-meshheading:12559795-Adult,
pubmed-meshheading:12559795-Aged,
pubmed-meshheading:12559795-Dose-Response Relationship, Immunologic,
pubmed-meshheading:12559795-Female,
pubmed-meshheading:12559795-Follow-Up Studies,
pubmed-meshheading:12559795-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:12559795-Hepatitis B Antibodies,
pubmed-meshheading:12559795-Hepatitis B Vaccines,
pubmed-meshheading:12559795-Humans,
pubmed-meshheading:12559795-Immunization, Secondary,
pubmed-meshheading:12559795-Injections, Intramuscular,
pubmed-meshheading:12559795-Male,
pubmed-meshheading:12559795-Middle Aged,
pubmed-meshheading:12559795-Vaccines, Synthetic
|
pubmed:year |
2003
|
pubmed:articleTitle |
Revaccination of healthy nonresponders with hepatitis B vaccine and prediction of seroprotection response.
|
pubmed:affiliation |
Clinical Pharmacology Research Center, Bassett Healthcare, One Atwell Road, Cooperstown, NY 13326-1394, USA.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|