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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11-12
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pubmed:dateCreated |
2003-1-31
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pubmed:abstractText |
Coupling of carbohydrate antigens to protein carriers is a typical approach to enhancing the immunogenicity of carbohydrate-based vaccines. Glycoconjugates with well-defined structures are needed for studies defining the structural variables that govern antibody responses. We report a chemical strategy for preparation of an array of glycoconjugates containing saccharides of desired molecular sizes by selective depolymerization of bacterial polysaccharides and chemically controlled site-specific coupling. As an example, we synthesized and evaluated an oligosaccharide-based vaccine against type III group B Streptococcus.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Capsules,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclobutanes,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Oligosaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Polysaccharides, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Streptococcal Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/group B streptococcal type III...,
http://linkedlifedata.com/resource/pubmed/chemical/squaric acid,
http://linkedlifedata.com/resource/pubmed/chemical/streptococcal polysaccharide type...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0264-410X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2002 Elsevier Science Ltd.
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1112-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12559788-Animals,
pubmed-meshheading:12559788-Antibodies, Bacterial,
pubmed-meshheading:12559788-Antigens, Bacterial,
pubmed-meshheading:12559788-Bacterial Capsules,
pubmed-meshheading:12559788-Carbohydrate Conformation,
pubmed-meshheading:12559788-Carbohydrate Sequence,
pubmed-meshheading:12559788-Cyclobutanes,
pubmed-meshheading:12559788-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:12559788-Female,
pubmed-meshheading:12559788-Glycoconjugates,
pubmed-meshheading:12559788-Mice,
pubmed-meshheading:12559788-Mice, Inbred BALB C,
pubmed-meshheading:12559788-Molecular Sequence Data,
pubmed-meshheading:12559788-Molecular Weight,
pubmed-meshheading:12559788-Oligosaccharides,
pubmed-meshheading:12559788-Polysaccharides, Bacterial,
pubmed-meshheading:12559788-Streptococcal Vaccines,
pubmed-meshheading:12559788-Streptococcus agalactiae
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pubmed:year |
2003
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pubmed:articleTitle |
Construction of designer glycoconjugate vaccines with size-specific oligosaccharide antigens and site-controlled coupling.
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pubmed:affiliation |
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA. ywang@channing.harvard.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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