Linked Life Data

12558524

Source:http://linkedlifedata.com/resource/pubmed/id/12558524

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-1-31
pubmed:abstractText
The contribution of B1 and B2 bradykinin receptors to germ cell proliferation was studied by using in vitro organ cultures of testicular fragments of 3.5-day-old rats in the presence of 3H thymidine. Different combinations of agonists and antagonists of B1 and B2 receptors exerted differential mitogenic effect on pro-spermatogonial cells. Application of bradykinin (B2 receptor agonist) alone induced a threefold increase in germ cell labelling index compared with the control, whereas des-Arg9-bradykinin (B1 receptor agonist) caused weak stimulation (24%) on spermatogonial mitotic activity. The bradykinin-induced germ cell proliferation was significantly affected by B2 receptor antagonist (HOE-140) but not by B1 receptor antagonist. When B1 or B2 receptor antagonists were applied with des-Arg9-bradykinin, the germ cell labelling indices were nonsignificantly different compared with those of B1 receptor agonist only. The present findings suggest that B2 receptor is involved in mediating the stimulatory effect of bradykinin on germ cell proliferation and therefore bradykinin might be an important local testicular factor in the regulation of spermatogonial division and germ cell number.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0303-4569
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
B2 bradykinin receptor mediates the stimulatory effect of bradykinin on rat germ cell proliferation in vitro.
pubmed:affiliation
Institute of Experimental Morphology and Anthropology, Bulgarian Academy of Sciences, Sofia, Bulgaria. ninaatana@hotmail.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't