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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-1-30
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pubmed:abstractText |
Enterotoxigenic Bacteroides fragilis that secrete a zinc-dependent metalloprotease toxin termed the B. fragilis toxin (BFT) have been associated with acute diarrheal disease. BFT rapidly cleaves the extracellular domain of E-cadherin, leading to the complete degradation of the E-cadherin protein. E-cadherin is the primary intercellular adhesion protein of the zonula adherens, and its cytoplasmic domain associates with the nuclear signaling protein beta-catenin. The goal of this study was to examine if BFT triggers beta-catenin nuclear signaling in intestinal epithelial cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Toxins,
http://linkedlifedata.com/resource/pubmed/chemical/Bacteroides fragilis toxin,
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enterotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Metalloendopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-myc,
http://linkedlifedata.com/resource/pubmed/chemical/TCF Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/TCF7L2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor 7-Like 2...,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
124
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
392-400
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12557145-Bacterial Toxins,
pubmed-meshheading:12557145-Biological Transport,
pubmed-meshheading:12557145-Cell Division,
pubmed-meshheading:12557145-Cell Nucleus,
pubmed-meshheading:12557145-Colon,
pubmed-meshheading:12557145-Cytoplasm,
pubmed-meshheading:12557145-Cytoskeletal Proteins,
pubmed-meshheading:12557145-Enterotoxins,
pubmed-meshheading:12557145-Humans,
pubmed-meshheading:12557145-Intestinal Mucosa,
pubmed-meshheading:12557145-Metalloendopeptidases,
pubmed-meshheading:12557145-Protein Biosynthesis,
pubmed-meshheading:12557145-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:12557145-Signal Transduction,
pubmed-meshheading:12557145-TCF Transcription Factors,
pubmed-meshheading:12557145-Tissue Distribution,
pubmed-meshheading:12557145-Trans-Activators,
pubmed-meshheading:12557145-Transcription, Genetic,
pubmed-meshheading:12557145-Transcription Factor 7-Like 2 Protein,
pubmed-meshheading:12557145-Transcription Factors,
pubmed-meshheading:12557145-Tumor Cells, Cultured,
pubmed-meshheading:12557145-beta Catenin
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pubmed:year |
2003
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pubmed:articleTitle |
Bacteroides fragilis enterotoxin induces c-Myc expression and cellular proliferation.
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pubmed:affiliation |
Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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