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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-1-30
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pubmed:abstractText |
Doxifluridine (5'-deoxy 5-fluorouridine) is an oral anticancer drug with antiangiogenic effects, with vasoclastic action that is enhanced by a major member of the pyrimidine phosphorylases, thymidine phosphorylase (TP). Previous studies have demonstrated that TP is upregulated in the lesions where pathologic angiogenesis occurs and TP itself promotes angiogenesis. To investigate the possible role of TP and doxifluridine in choroidal neovascularization (CNV), the expression level of TP was measured and the effect of doxifluridine was investigated in rat eyes with experimental CNV.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
751-4
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pubmed:dateRevised |
2005-10-18
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pubmed:meshHeading |
pubmed-meshheading:12556409-Administration, Oral,
pubmed-meshheading:12556409-Animals,
pubmed-meshheading:12556409-Antimetabolites, Antineoplastic,
pubmed-meshheading:12556409-Choroidal Neovascularization,
pubmed-meshheading:12556409-Chromatography, High Pressure Liquid,
pubmed-meshheading:12556409-Conjunctiva,
pubmed-meshheading:12556409-Disease Models, Animal,
pubmed-meshheading:12556409-Enzyme Activation,
pubmed-meshheading:12556409-Female,
pubmed-meshheading:12556409-Floxuridine,
pubmed-meshheading:12556409-Fluorescein Angiography,
pubmed-meshheading:12556409-Injections,
pubmed-meshheading:12556409-Rats,
pubmed-meshheading:12556409-Rats, Inbred BN,
pubmed-meshheading:12556409-Thymidine Phosphorylase
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pubmed:year |
2003
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pubmed:articleTitle |
Subconjunctival doxifluridine administration suppresses rat choroidal neovascularization through activated thymidine phosphorylase.
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pubmed:affiliation |
Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan. yanagi-tky@umin.ac.jp
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pubmed:publicationType |
Journal Article
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