Source:http://linkedlifedata.com/resource/pubmed/id/12555236
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2003-1-29
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pubmed:abstractText |
Our previous study has suggested that the TaqI A polymorphism of dopamine D2 receptor gene (DRD2) is associated with the predisposition to neuroleptic malignant syndrome (NMS). However, the specificity of this polymorphism as a predictor of NMS dose not seem to be sufficient enough. Meanwhile, it has been shown that the non-carriers of Del allele of the -141C Ins/Del polymorphism in the promoter region of DRD2 have lower dopamine D2 receptor in the brain than the carriers. In addition, dopamine D3 receptor gene has a Ser(9)Gly polymorphism, which may alter the receptor function. The present study examined the association between these three polymorphisms and the development of NMS to investigate if a combination of these polymorphisms could increase the specificity as markers for NMS. The subjects were 17 psychiatric patients who had developed NMS (13 patients with schizophrenia, 3 with major depression, and 1 with dementia of the Alzheimer's type) and 163 schizophrenic patients who had never developed this syndrome. The frequency of the A1 allele was significantly (P = 0.012) higher in the patients who had developed NMS (59%) than in the patients who had not (35%). The proportion of the A1 carriers was significantly (P = 0.003) higher in the patients with NMS (16/17: 94%) than in those without the syndrome (93/163: 57%). However, no significant differences were found in the allele and genotype frequencies of the other two polymorphisms between the two groups. The present study suggests that only the TaqI A polymorphism is at least partly useful as a predictor of NMS, but the -141 C Ins/Del and Ser(9)Gly polymorphisms are not.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DRD3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyribonucleases, Type II...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D3,
http://linkedlifedata.com/resource/pubmed/chemical/TCGA-specific type II...
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1552-4841
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2003 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
117B
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
57-60
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pubmed:dateRevised |
2008-8-29
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pubmed:meshHeading |
pubmed-meshheading:12555236-Adult,
pubmed-meshheading:12555236-Deoxyribonucleases, Type II Site-Specific,
pubmed-meshheading:12555236-Depression,
pubmed-meshheading:12555236-Female,
pubmed-meshheading:12555236-Gene Frequency,
pubmed-meshheading:12555236-Genetic Predisposition to Disease,
pubmed-meshheading:12555236-Genotype,
pubmed-meshheading:12555236-Humans,
pubmed-meshheading:12555236-Male,
pubmed-meshheading:12555236-Middle Aged,
pubmed-meshheading:12555236-Neuroleptic Malignant Syndrome,
pubmed-meshheading:12555236-Polymorphism, Genetic,
pubmed-meshheading:12555236-Receptors, Dopamine D2,
pubmed-meshheading:12555236-Receptors, Dopamine D3,
pubmed-meshheading:12555236-Schizophrenia
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pubmed:year |
2003
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pubmed:articleTitle |
Relationship between functional dopamine D2 and D3 receptors gene polymorphisms and neuroleptic malignant syndrome.
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pubmed:affiliation |
Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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