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pubmed:abstractText |
Neuroblastoma and melanoma cells have a common embryonal origin. In contrast to melanoma, most neuroblastoma tumours preferentially metastasize into bone marrow. Previously, we described that bone marrow-conditioned medium (BM-CM) supports the proliferation of catecholamine-producing (N-type) neuroblastoma (SK-N-SH, IMR-32, Kelly)-, but not of melanoma cells. Both neuroblastoma and melanoma produce DOPA (3,4 dihydroxyphenylalanine); while melanoma cells use tyrosinase for DOPA synthesis, neuroblastoma cells usually utilize tyrosine hydroxylase.
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