12553028

Source:http://linkedlifedata.com/resource/pubmed/id/12553028

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0013081, umls-concept:C0086418, umls-concept:C0162638, umls-concept:C0334227, umls-concept:C0376515, umls-concept:C0684249, umls-concept:C1336767
pubmed:issue	6C
pubmed:dateCreated	2003-1-29
pubmed:abstractText	Anticancer drug-induced apoptosis is one of the important mechanisms in the effectiveness of chemotherapy. In this study, we investigated apoptosis induced by topoisomerase inhibitors and its relationship with chemosensitivity, the expression of Bcl-2 family proteins and p53 status in human lung cancer cells.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8102988
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic, http://linkedlifedata.com/resource/pubmed/chemical/BAX protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Camptothecin, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Etoposide, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2, http://linkedlifedata.com/resource/pubmed/chemical/Topoisomerase I Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Topoisomerase II Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53, http://linkedlifedata.com/resource/pubmed/chemical/bcl-2-Associated X Protein, http://linkedlifedata.com/resource/pubmed/chemical/irinotecan
pubmed:status	MEDLINE
pubmed:issn	0250-7005
pubmed:author	pubmed-author:Dosaka-AkitaHirotoshiH, pubmed-author:IshidaTakashiT, pubmed-author:IsobeHiroshiH, pubmed-author:KawakamiYoshikazuY, pubmed-author:NishimuraMasaharuM, pubmed-author:OguraShigeakiS, pubmed-author:OizumiSatoshiS, pubmed-author:YamazakiKoichiK
pubmed:issnType	Print
pubmed:volume	22
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	4029-37
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:12553028-Antineoplastic Agents, Phytogenic, pubmed-meshheading:12553028-Apoptosis, pubmed-meshheading:12553028-Camptothecin, pubmed-meshheading:12553028-Carcinoma, Non-Small-Cell Lung, pubmed-meshheading:12553028-Carcinoma, Small Cell, pubmed-meshheading:12553028-Down-Regulation, pubmed-meshheading:12553028-Enzyme Inhibitors, pubmed-meshheading:12553028-Etoposide, pubmed-meshheading:12553028-Flow Cytometry, pubmed-meshheading:12553028-Humans, pubmed-meshheading:12553028-Lung Neoplasms, pubmed-meshheading:12553028-Proto-Oncogene Proteins, pubmed-meshheading:12553028-Proto-Oncogene Proteins c-bcl-2, pubmed-meshheading:12553028-Topoisomerase I Inhibitors, pubmed-meshheading:12553028-Topoisomerase II Inhibitors, pubmed-meshheading:12553028-Tumor Cells, Cultured, pubmed-meshheading:12553028-Tumor Suppressor Protein p53, pubmed-meshheading:12553028-bcl-2-Associated X Protein
pubmed:articleTitle	Topoisomerase inhibitor-induced apoptosis accompanied by down-regulation of Bcl-2 in human lung cancer cells.
pubmed:affiliation	First Department of Medicine, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan.
pubmed:publicationType	Journal Article