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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6B
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pubmed:dateCreated |
2003-1-29
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pubmed:abstractText |
This study assessed the efficacy of combined prophylactic and curative anti-diarrhoeal medication in advanced colorectal patients treated by irinotecan. Thirty-four pre-treated eligible patients were evaluated. There were 44% women, the median age was 65 and 38% of the patients had a 0 performance status. The patients received sucralfate(4g/d) and nifuroxazide(600 mg/d) prophylactic treatment on days 0-7. In the case of severe diarrhoea, preventive treatment was replaced by loperamide(12 mg/d) and diosmectite (9 g/d). Grade 3 delayed diarrhoea occurred in 18% of patients (90% CI: [9.5-28.9]) and 4.6% of cycles. No grade 4 delayed diarrhoea was observed. Twenty-nine patients (85%) received the preventive treatment at cycle 1, while 14% (90% CI: [6.2-25.7]) experienced grade 3 delayed diarrhoea in 3.7% of cycles for a median 4.5 days. The objective response rate was 8% (90% CI [1.4-23.1]) among the 25 assessable patients. Preventive combined treatment is effective in reducing the incidence of severe delayed diarrhoea, and it should be proposed to patients treated with mono-therapy Campto(r) and evaluated in poly-chemotherapy protocols.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Infective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Ulcer Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antidiarrheals,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic,
http://linkedlifedata.com/resource/pubmed/chemical/Camptothecin,
http://linkedlifedata.com/resource/pubmed/chemical/Gastrointestinal Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxybenzoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Loperamide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrofurans,
http://linkedlifedata.com/resource/pubmed/chemical/Silicates,
http://linkedlifedata.com/resource/pubmed/chemical/Smectite,
http://linkedlifedata.com/resource/pubmed/chemical/Sucralfate,
http://linkedlifedata.com/resource/pubmed/chemical/irinotecan,
http://linkedlifedata.com/resource/pubmed/chemical/nifuroxazide
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pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3727-31
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:12552984-Adenocarcinoma,
pubmed-meshheading:12552984-Adult,
pubmed-meshheading:12552984-Aged,
pubmed-meshheading:12552984-Anti-Infective Agents,
pubmed-meshheading:12552984-Anti-Ulcer Agents,
pubmed-meshheading:12552984-Antidiarrheals,
pubmed-meshheading:12552984-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:12552984-Camptothecin,
pubmed-meshheading:12552984-Colorectal Neoplasms,
pubmed-meshheading:12552984-Diarrhea,
pubmed-meshheading:12552984-Gastrointestinal Agents,
pubmed-meshheading:12552984-Humans,
pubmed-meshheading:12552984-Hydroxybenzoic Acids,
pubmed-meshheading:12552984-Loperamide,
pubmed-meshheading:12552984-Middle Aged,
pubmed-meshheading:12552984-Nitrofurans,
pubmed-meshheading:12552984-Silicates,
pubmed-meshheading:12552984-Sucralfate
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pubmed:articleTitle |
Efficacy of prophylactic anti-diarrhoeal treatment in patients receiving Campto for advanced colorectal cancer.
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pubmed:affiliation |
Hopital La Timone, 264 rue St-Pierre, Marseille, France.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Multicenter Study
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