rdf:type |
|
lifeskim:mentions |
umls-concept:C0011306,
umls-concept:C0019704,
umls-concept:C0033684,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0205369,
umls-concept:C0871261,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1704632,
umls-concept:C1706438,
umls-concept:C1706817,
umls-concept:C2346689,
umls-concept:C2698600,
umls-concept:C2911692
|
pubmed:issue |
2
|
pubmed:dateCreated |
2003-1-28
|
pubmed:abstractText |
Proteins may serve as ideal CD8(+) T cell immunogens for human immunodeficiency virus type 1 (HIV-1) if they can be delivered to and processed through the human leukocyte antigen class I pathway. This study shows that human blood monocyte-derived dendritic cells loaded with liposome-complexed HIV-1 proteins and matured with CD40 ligand can prime CD8(+) T cells to HIV-1 in vitro. Whole HIV-1 protein in liposome may be an effective immunogen for HIV-1 vaccine protocols.
|
pubmed:grant |
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0022-1899
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
187
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
315-9
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:12552458-AIDS Vaccines,
pubmed-meshheading:12552458-CD40 Ligand,
pubmed-meshheading:12552458-CD8-Positive T-Lymphocytes,
pubmed-meshheading:12552458-Cell Membrane,
pubmed-meshheading:12552458-Cells, Cultured,
pubmed-meshheading:12552458-Dendritic Cells,
pubmed-meshheading:12552458-HIV Antigens,
pubmed-meshheading:12552458-HIV-1,
pubmed-meshheading:12552458-Humans,
pubmed-meshheading:12552458-Liposomes,
pubmed-meshheading:12552458-Lymphocyte Activation,
pubmed-meshheading:12552458-Phosphatidylethanolamines
|
pubmed:year |
2003
|
pubmed:articleTitle |
Priming of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cell responses by dendritic cells loaded with HIV-1 proteins.
|
pubmed:affiliation |
Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|