Source:http://linkedlifedata.com/resource/pubmed/id/12552446
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2003-1-28
|
| pubmed:abstractText |
The relationship among CCR5 genotype, cytomegalovirus infection, and disease progression and death was studied among 159 human immunodeficiency virus (HIV)-infected patients with hemophilia. One patient (0.6%) had the CCR5Delta32/CCR5Delta32 genotype (which occurs in approximately 2% of the Scandinavian population) and a rapid disease course. His HIV V3 region contained genotypic features attributable to X4 virus and resembled functionally verified X4 virus and virus from patients treated with a CD4 cell-stimulating drug, tucaresol. Age-related differences in disease progression rate and survival time were seen for CCR5/CCR5 patients. Surprisingly, no protective effect of the CCR5/CCR5Delta32 genotype on disease progression or survival was seen for children but was evident for adults. Age group-related immunologic differences might explain this variation, and transmission route and/or viral phenotype variation within donor virus may be related to the limited protection of the CCR5Delta32/CCR5Delta32 genotype. Sequence comparisons indicate that X4 virus can be selected in vivo due to either absence of CCR5 receptors or relative increase of CXCR4 receptors.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0022-1899
|
| pubmed:author |
pubmed-author:AttermannJørnJ,
pubmed-author:BerntorpErikE,
pubmed-author:ChristiansenClaus BohnCB,
pubmed-author:DickmeissEbbeE,
pubmed-author:Eugen-OlsenJesperJ,
pubmed-author:FuggerLarsL,
pubmed-author:GerstoftJanJ,
pubmed-author:IngerslevJørgenJ,
pubmed-author:IversenAstrid K NAK,
pubmed-author:ScheibelElmaE,
pubmed-author:SchulmanSamS,
pubmed-author:SkinhøjPeterP,
pubmed-author:SvejgaardArneA,
pubmed-author:TengbornLillianL
|
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
187
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
215-25
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:12552446-Adolescent,
pubmed-meshheading:12552446-Adult,
pubmed-meshheading:12552446-Aging,
pubmed-meshheading:12552446-Amino Acid Sequence,
pubmed-meshheading:12552446-CD4 Lymphocyte Count,
pubmed-meshheading:12552446-Cohort Studies,
pubmed-meshheading:12552446-Cytomegalovirus Infections,
pubmed-meshheading:12552446-Disease Progression,
pubmed-meshheading:12552446-Female,
pubmed-meshheading:12552446-Genetic Predisposition to Disease,
pubmed-meshheading:12552446-Genotype,
pubmed-meshheading:12552446-HIV,
pubmed-meshheading:12552446-HIV Infections,
pubmed-meshheading:12552446-Hemophilia A,
pubmed-meshheading:12552446-Hemophilia B,
pubmed-meshheading:12552446-Humans,
pubmed-meshheading:12552446-Incidence,
pubmed-meshheading:12552446-Male,
pubmed-meshheading:12552446-Middle Aged,
pubmed-meshheading:12552446-Molecular Sequence Data,
pubmed-meshheading:12552446-Receptors, CCR5,
pubmed-meshheading:12552446-Risk Factors,
pubmed-meshheading:12552446-Survival Rate
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Limited protective effect of the CCR5Delta32/CCR5Delta32 genotype on human immunodeficiency virus infection incidence in a cohort of patients with hemophilia and selection for genotypic X4 virus.
|
| pubmed:affiliation |
Department of Medical Microbiology and Immunology, Arhus University School of Medicine, Denmark. aifrhm@inet.uni2.dk
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|