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pubmed-article:12552198pubmed:abstractTextIschemia causes an imbalance in mitochondrial metabolism and accumulation of nicotinamide adenine dinucleotide (NADH). We showed that anesthetic preconditioning (APC), like ischemic preconditioning, improved mitochondrial NADH energy balance during ischemia and improved function and reduced infarct size on reperfusion. Opening adenosine triphosphate-sensitive potassium (K(atp)) channels may be involved in triggering APC. The authors tested if effects of APC on NADH concentrations before, during, and after ischemia are reversible by 5-hydroxydecanoate (5-HD), a putative mitochondrial K channel blocker.lld:pubmed
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pubmed-article:12552198pubmed:articleTitlePreconditioning with sevoflurane reduces changes in nicotinamide adenine dinucleotide during ischemia-reperfusion in isolated hearts: reversal by 5-hydroxydecanoic acid.lld:pubmed
pubmed-article:12552198pubmed:affiliationDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA.lld:pubmed
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