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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-1-28
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pubmed:abstractText |
Ischemia causes an imbalance in mitochondrial metabolism and accumulation of nicotinamide adenine dinucleotide (NADH). We showed that anesthetic preconditioning (APC), like ischemic preconditioning, improved mitochondrial NADH energy balance during ischemia and improved function and reduced infarct size on reperfusion. Opening adenosine triphosphate-sensitive potassium (K(atp)) channels may be involved in triggering APC. The authors tested if effects of APC on NADH concentrations before, during, and after ischemia are reversible by 5-hydroxydecanoate (5-HD), a putative mitochondrial K channel blocker.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5-hydroxydecanoic acid,
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Inhalation,
http://linkedlifedata.com/resource/pubmed/chemical/Decanoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxy Acids,
http://linkedlifedata.com/resource/pubmed/chemical/KATP Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Methyl Ethers,
http://linkedlifedata.com/resource/pubmed/chemical/NAD,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Inwardly...,
http://linkedlifedata.com/resource/pubmed/chemical/sevoflurane,
http://linkedlifedata.com/resource/pubmed/chemical/uK-ATP-1 potassium channel
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0003-3022
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
387-95
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12552198-ATP-Binding Cassette Transporters,
pubmed-meshheading:12552198-Anesthetics, Inhalation,
pubmed-meshheading:12552198-Animals,
pubmed-meshheading:12552198-Blood Pressure,
pubmed-meshheading:12552198-Coronary Circulation,
pubmed-meshheading:12552198-Decanoic Acids,
pubmed-meshheading:12552198-Fluorescence,
pubmed-meshheading:12552198-Guinea Pigs,
pubmed-meshheading:12552198-Heart,
pubmed-meshheading:12552198-Hydroxy Acids,
pubmed-meshheading:12552198-Ischemic Preconditioning, Myocardial,
pubmed-meshheading:12552198-KATP Channels,
pubmed-meshheading:12552198-Male,
pubmed-meshheading:12552198-Methyl Ethers,
pubmed-meshheading:12552198-Mitochondria, Heart,
pubmed-meshheading:12552198-Myocardial Contraction,
pubmed-meshheading:12552198-Myocardial Infarction,
pubmed-meshheading:12552198-Myocardial Ischemia,
pubmed-meshheading:12552198-Myocardium,
pubmed-meshheading:12552198-NAD,
pubmed-meshheading:12552198-Potassium Channel Blockers,
pubmed-meshheading:12552198-Potassium Channels,
pubmed-meshheading:12552198-Potassium Channels, Inwardly Rectifying,
pubmed-meshheading:12552198-Ventricular Function, Left
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pubmed:year |
2003
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pubmed:articleTitle |
Preconditioning with sevoflurane reduces changes in nicotinamide adenine dinucleotide during ischemia-reperfusion in isolated hearts: reversal by 5-hydroxydecanoic acid.
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pubmed:affiliation |
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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