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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-1-27
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pubmed:abstractText |
Hepatic lipase (HL) is involved in the metabolism of several lipoproteins and may contribute to the atherogenic lipid profile in type 2 diabetes. Little is known about the effect of cholesterol synthesis inhibitors on HL activity in relation to sex and the hepatic lipase gene, the LIPC promoter variant in type 2 diabetes. Therefore, we studied the effect of atorvastatin 10 mg (A10) and 80 mg (A80) on HL activity in 198 patients with type 2 diabetes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0149-5992
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
427-32
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12547874-African Continental Ancestry Group,
pubmed-meshheading:12547874-Aged,
pubmed-meshheading:12547874-Alleles,
pubmed-meshheading:12547874-Diabetes Mellitus, Type 2,
pubmed-meshheading:12547874-Dose-Response Relationship, Drug,
pubmed-meshheading:12547874-Double-Blind Method,
pubmed-meshheading:12547874-Enzyme Inhibitors,
pubmed-meshheading:12547874-European Continental Ancestry Group,
pubmed-meshheading:12547874-Female,
pubmed-meshheading:12547874-Genetic Variation,
pubmed-meshheading:12547874-Heptanoic Acids,
pubmed-meshheading:12547874-Heterozygote,
pubmed-meshheading:12547874-Humans,
pubmed-meshheading:12547874-Hyperlipidemias,
pubmed-meshheading:12547874-Lipase,
pubmed-meshheading:12547874-Liver,
pubmed-meshheading:12547874-Male,
pubmed-meshheading:12547874-Middle Aged,
pubmed-meshheading:12547874-Polymorphism, Genetic,
pubmed-meshheading:12547874-Promoter Regions, Genetic,
pubmed-meshheading:12547874-Pyrroles,
pubmed-meshheading:12547874-Sex Characteristics
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pubmed:year |
2003
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pubmed:articleTitle |
Atorvastatin dose-dependently decreases hepatic lipase activity in type 2 diabetes: effect of sex and the LIPC promoter variant.
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pubmed:affiliation |
Department of Internal Medicine, Erasmus MC, Erasmus University Rotterdam, the Netherlands.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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