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rdf:type |
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lifeskim:mentions |
umls-concept:C0005684,
umls-concept:C0017262,
umls-concept:C0035820,
umls-concept:C0079427,
umls-concept:C0185117,
umls-concept:C0205210,
umls-concept:C0332281,
umls-concept:C1274040,
umls-concept:C1325410,
umls-concept:C1517945,
umls-concept:C1708598,
umls-concept:C1947901,
umls-concept:C2911684
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pubmed:issue |
2
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pubmed:dateCreated |
2003-1-27
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pubmed:abstractText |
The expression profiles of nine bladder cancer cell lines were compared against a pool containing equal total RNA quantities of each of them. Lower expression of KiSS-1 was revealed in cells derived from the most advanced bladder tumors. When comparing 15 primary bladder tumors versus a pool of four bladder cancer cell lines, lower transcript levels of KiSS-1 were observed in the invasive bladder carcinomas as compared to superficial tumors. KiSS-1 expression ratios provided prognostic information. The expression pattern of KiSS-1 transcripts was analyzed using in situ hybridization in nine bladder cancer cells, paired normal urothelium and bladder tumor samples (n = 25), and tissue microarrays of bladder tumors (n = 173). We observed complete loss of KiSS-1 in all invasive tumors under study as compared to their respective normal urothelium. The expression of KiSS-1 was found to be significantly associated with histopathological stage. Patients with lower KiSS-1 expression showed a direct correlation with overall survival in a subset of bladder tumors whose follow-up was available (n = 69). We did not observe any significant differential KiSS-1 expression along cell cycle by sorting analysis. A potential tumor suppressor role in bladder cancer was revealed for KiSS-1. Moreover, it showed predictive value by identifying patients with poor outcome.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-10214355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-10360823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-10521349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-10700174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-10748532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-11015604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-11029508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-11060311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-11290542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-11385580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-11387329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-11457843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-11527393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-11592309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-11606374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-11801555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-11994395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-12013533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-1698118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-7958891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-8302587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-8634087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-8944003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-9185708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-9192814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-9785004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-9806840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-9828832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-9843981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12547718-9850064
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
162
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
609-17
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12547718-Adult,
pubmed-meshheading:12547718-Aged,
pubmed-meshheading:12547718-Aged, 80 and over,
pubmed-meshheading:12547718-Carcinoma in Situ,
pubmed-meshheading:12547718-Disease Progression,
pubmed-meshheading:12547718-Female,
pubmed-meshheading:12547718-Genes, Retinoblastoma,
pubmed-meshheading:12547718-Genes, Tumor Suppressor,
pubmed-meshheading:12547718-Genes, p53,
pubmed-meshheading:12547718-Humans,
pubmed-meshheading:12547718-In Situ Hybridization,
pubmed-meshheading:12547718-Kisspeptins,
pubmed-meshheading:12547718-Male,
pubmed-meshheading:12547718-Middle Aged,
pubmed-meshheading:12547718-Neoplasm Staging,
pubmed-meshheading:12547718-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:12547718-Proteins,
pubmed-meshheading:12547718-Smoking,
pubmed-meshheading:12547718-Survival Analysis,
pubmed-meshheading:12547718-Time Factors,
pubmed-meshheading:12547718-Treatment Outcome,
pubmed-meshheading:12547718-Tumor Cells, Cultured,
pubmed-meshheading:12547718-Tumor Suppressor Proteins,
pubmed-meshheading:12547718-Urinary Bladder Neoplasms
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pubmed:year |
2003
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pubmed:articleTitle |
Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome.
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pubmed:affiliation |
Division of Molecular Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA. sanchezm@mskcc.org
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pubmed:publicationType |
Journal Article
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