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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2003-2-6
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pubmed:abstractText |
Differential methylation of the two alleles is a hallmark of imprinted genes. Correspondingly, loss of DNA methyltransferase function results in aberrant imprinting and abnormal post-fertilization development. In the mouse, mutations of the oocyte-specific isoform of the DNA methyltransferase Dnmt1 (Dnmt1o) and of the methyltransferase-like Dnmt3L gene result in specific failures of imprint establishment or maintenance, at multiple loci. We have previously shown in humans that an analogous inherited failure to establish imprinting at multiple loci in the female germline underlies a rare phenotype of recurrent hydatidiform mole.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-10072436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-10508852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-10518555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-10551868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-10588719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-10647011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-10699182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-10857753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-11005794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-11067869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-11102980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-11290321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-11399089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-11719692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-11932746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-11934864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-12177302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-12202768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-12481029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-1606615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-3653008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-561314,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-6709062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-7795645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-8247133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-8634713,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/12546714-9830015
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1471-2156
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
20
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12546714-Animals,
pubmed-meshheading:12546714-Base Sequence,
pubmed-meshheading:12546714-DNA (Cytosine-5-)-Methyltransferase,
pubmed-meshheading:12546714-DNA Methylation,
pubmed-meshheading:12546714-DNA Modification Methylases,
pubmed-meshheading:12546714-DNA Mutational Analysis,
pubmed-meshheading:12546714-Exons,
pubmed-meshheading:12546714-Female,
pubmed-meshheading:12546714-Genomic Imprinting,
pubmed-meshheading:12546714-Humans,
pubmed-meshheading:12546714-Hydatidiform Mole,
pubmed-meshheading:12546714-Isoenzymes,
pubmed-meshheading:12546714-Mice,
pubmed-meshheading:12546714-Microsatellite Repeats,
pubmed-meshheading:12546714-Molecular Sequence Data,
pubmed-meshheading:12546714-Mutation,
pubmed-meshheading:12546714-Oocytes,
pubmed-meshheading:12546714-Pregnancy,
pubmed-meshheading:12546714-Sequence Homology, Nucleic Acid,
pubmed-meshheading:12546714-Uterine Neoplasms
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pubmed:year |
2003
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pubmed:articleTitle |
Lack of involvement of known DNA methyltransferases in familial hydatidiform mole implies the involvement of other factors in establishment of imprinting in the human female germline.
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pubmed:affiliation |
Molecular Medicine Unit, University of Leeds, Leeds LS9 7TF, UK. b.hayward@leeds.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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