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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2004-7-16
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pubmed:abstractText |
One approach to resolving some of the in vivo functions of alpha-crystallin is to generate animal models where one or both of the alpha-crystallin gene products have been eliminated. In the single alpha-crystallin knockout mice, the remaining alpha-crystallin may fully or partially compensate for some of the functions of the missing protein, especially in the lens, where both alpha A and alpha B are normally expressed at high levels. The purpose of this study was to characterize gross lenticular morphology in normal mice and mice with the targeted disruption of alpha A- and alpha B-crystallin genes (alpha A/BKO).
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546709-10099937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546709-10625651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546709-10627817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546709-10811949,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/12546709-1429679,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/12546709-2725488,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/12546709-561720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12546709-618891,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/12546709-8039702,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/12546709-8547304,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/12546709-9813033
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1471-2415
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
24
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12546709-Animals,
pubmed-meshheading:12546709-Cataract,
pubmed-meshheading:12546709-Gene Deletion,
pubmed-meshheading:12546709-Lens, Crystalline,
pubmed-meshheading:12546709-Mice,
pubmed-meshheading:12546709-Mice, Knockout,
pubmed-meshheading:12546709-Microscopy, Confocal,
pubmed-meshheading:12546709-Microscopy, Electron, Scanning,
pubmed-meshheading:12546709-alpha-Crystallin A Chain,
pubmed-meshheading:12546709-alpha-Crystallin B Chain
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pubmed:year |
2003
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pubmed:articleTitle |
Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens.
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pubmed:affiliation |
Kansas State University, Division of Biology, Ackert Hall, Manhattan, KS, USA. dboyle@ksu.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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