Linked Life Data

12546700

Source:http://linkedlifedata.com/resource/pubmed/id/12546700

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 1
pubmed:dateCreated
2003-1-27
pubmed:abstractText
Phosphoinositide 3-kinases (PI3Ks) are important signalling enzymes in most cell types. Recent gene targeting studies have shed light on the importance of this family of lipid kinases in the immune system, and the complex mechanisms by which these kinases are regulated in vivo. We have recently reported a phenotype of mice in which the p110 delta PI3K catalytic subunit was inactivated by point mutation. In the present paper, we compare and contrast the phenotypes of p110 delta mutant mice with those of mice that lack p85 alpha or p110 gamma, and discuss these in the context of PI3K signalling in B- and T-cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0300-5127
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
270-4
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
PI3K-signalling in B- and T-cells: insights from gene-targeted mice.
pubmed:affiliation
Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, UK.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't