| pubmed-article:12545169 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12545169 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12545169 | lifeskim:mentions | umls-concept:C1420445 | lld:lifeskim |
| pubmed-article:12545169 | lifeskim:mentions | umls-concept:C0152018 | lld:lifeskim |
| pubmed-article:12545169 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:12545169 | lifeskim:mentions | umls-concept:C1261322 | lld:lifeskim |
| pubmed-article:12545169 | lifeskim:mentions | umls-concept:C0524869 | lld:lifeskim |
| pubmed-article:12545169 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12545169 | pubmed:dateCreated | 2003-1-24 | lld:pubmed |
| pubmed-article:12545169 | pubmed:abstractText | Frequent loss of heterozygosity (LOH) on human chromosome 7q31 has been reported in numerous malignancies. Suppressor of tumorigenicity 7 (ST7) has been identified as a candidate tumor suppressor gene in this region. To identify whether 7q31 and genetic alterations of ST7 were involved in human esophageal carcinogenesis, we performed LOH mapping of a 5.4 cM region at 7q31-q35 in 43 primary esophageal carcinomas, as well as mutational analyses of the ST7 gene in tumors with LOH in this region. Of 43 tumors, 12 (28%) showed LOH at 7q31-q35. These included four (22%) of 18 squamous cell carcinomas and eight (32%) of 25 adenocarcinomas. The peak LOH locus was D7S480, lying 4.2 Mb telomeric to ST7 and showing LOH in eight of 37 informative tumors, or 22%. No mutations were found in the entire coding or flanking intronic regions of the ST7 gene among 12 tumors with 7q-LOH. In addition, quantitative RT-PCR analyses of ST7 mRNA expression levels in 11/13 normal-tumor pairs failed to show more than a 50% decrease in tumor ST7 mRNA relative to matched normal tissues. These data suggest that LOH at 7q31-q35 is involved in the origin or progression of at least a subset of esophageal carcinomas, but that ST7 is not the target gene of this somatic event. | lld:pubmed |
| pubmed-article:12545169 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12545169 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12545169 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12545169 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12545169 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12545169 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12545169 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12545169 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12545169 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12545169 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12545169 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12545169 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:12545169 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:12545169 | pubmed:author | pubmed-author:KlosIu SIuS | lld:pubmed |
| pubmed-article:12545169 | pubmed:author | pubmed-author:JuelE OEO | lld:pubmed |
| pubmed-article:12545169 | pubmed:author | pubmed-author:SatoFumiakiF | lld:pubmed |
| pubmed-article:12545169 | pubmed:author | pubmed-author:ShibataDavidD | lld:pubmed |
| pubmed-article:12545169 | pubmed:author | pubmed-author:MoriYurikoY | lld:pubmed |
| pubmed-article:12545169 | pubmed:author | pubmed-author:ZouTong-TongT... | lld:pubmed |
| pubmed-article:12545169 | pubmed:author | pubmed-author:WangSunaS | lld:pubmed |
| pubmed-article:12545169 | pubmed:author | pubmed-author:SelaruFlorin... | lld:pubmed |
| pubmed-article:12545169 | pubmed:author | pubmed-author:AbrahamJohn... | lld:pubmed |
| pubmed-article:12545169 | pubmed:author | pubmed-author:MeltzerStephe... | lld:pubmed |
| pubmed-article:12545169 | pubmed:author | pubmed-author:OlaruAndreeaA | lld:pubmed |
| pubmed-article:12545169 | pubmed:author | pubmed-author:SunMenghongM | lld:pubmed |
| pubmed-article:12545169 | pubmed:author | pubmed-author:GreenwaldBruc... | lld:pubmed |
| pubmed-article:12545169 | pubmed:author | pubmed-author:KimosMartha... | lld:pubmed |
| pubmed-article:12545169 | pubmed:author | pubmed-author:PerryKellieK | lld:pubmed |
| pubmed-article:12545169 | pubmed:author | pubmed-author:DeacuElenaE | lld:pubmed |
| pubmed-article:12545169 | pubmed:author | pubmed-author:ShiYing-Chang... | lld:pubmed |
| pubmed-article:12545169 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12545169 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:12545169 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:12545169 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12545169 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12545169 | pubmed:pagination | 467-70 | lld:pubmed |
| pubmed-article:12545169 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12545169 | pubmed:meshHeading | pubmed-meshheading:12545169... | lld:pubmed |
| pubmed-article:12545169 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12545169 | pubmed:articleTitle | An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma. | lld:pubmed |
| pubmed-article:12545169 | pubmed:affiliation | Department of Medicine, Division of Gastroenterology and Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore 21201, USA. | lld:pubmed |
| pubmed-article:12545169 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12545169 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12545169 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| entrez-gene:7982 | entrezgene:pubmed | pubmed-article:12545169 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12545169 | lld:entrezgene |
| lhgdn:association:57179 | lhgdn:found_in | pubmed-article:12545169 | lld:lhgdn |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12545169 | lld:pubmed |
