Source:http://linkedlifedata.com/resource/pubmed/id/12545169
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2003-1-24
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| pubmed:abstractText |
Frequent loss of heterozygosity (LOH) on human chromosome 7q31 has been reported in numerous malignancies. Suppressor of tumorigenicity 7 (ST7) has been identified as a candidate tumor suppressor gene in this region. To identify whether 7q31 and genetic alterations of ST7 were involved in human esophageal carcinogenesis, we performed LOH mapping of a 5.4 cM region at 7q31-q35 in 43 primary esophageal carcinomas, as well as mutational analyses of the ST7 gene in tumors with LOH in this region. Of 43 tumors, 12 (28%) showed LOH at 7q31-q35. These included four (22%) of 18 squamous cell carcinomas and eight (32%) of 25 adenocarcinomas. The peak LOH locus was D7S480, lying 4.2 Mb telomeric to ST7 and showing LOH in eight of 37 informative tumors, or 22%. No mutations were found in the entire coding or flanking intronic regions of the ST7 gene among 12 tumors with 7q-LOH. In addition, quantitative RT-PCR analyses of ST7 mRNA expression levels in 11/13 normal-tumor pairs failed to show more than a 50% decrease in tumor ST7 mRNA relative to matched normal tissues. These data suggest that LOH at 7q31-q35 is involved in the origin or progression of at least a subset of esophageal carcinomas, but that ST7 is not the target gene of this somatic event.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0950-9232
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| pubmed:author |
pubmed-author:AbrahamJohn MJM,
pubmed-author:DeacuElenaE,
pubmed-author:GreenwaldBruce DBD,
pubmed-author:JuelE OEO,
pubmed-author:KimosMartha CMC,
pubmed-author:KlosIu SIuS,
pubmed-author:MeltzerStephen JSJ,
pubmed-author:MoriYurikoY,
pubmed-author:OlaruAndreeaA,
pubmed-author:PerryKellieK,
pubmed-author:SatoFumiakiF,
pubmed-author:SelaruFlorin MFM,
pubmed-author:ShiYing-ChangYC,
pubmed-author:ShibataDavidD,
pubmed-author:SunMenghongM,
pubmed-author:WangSunaS,
pubmed-author:ZouTong-TongTT
|
| pubmed:issnType |
Print
|
| pubmed:day |
23
|
| pubmed:volume |
22
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
467-70
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:12545169-Adenocarcinoma,
pubmed-meshheading:12545169-Carcinoma,
pubmed-meshheading:12545169-Chromosomes, Human, Pair 7,
pubmed-meshheading:12545169-DNA, Intergenic,
pubmed-meshheading:12545169-Esophageal Neoplasms,
pubmed-meshheading:12545169-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:12545169-Humans,
pubmed-meshheading:12545169-Introns,
pubmed-meshheading:12545169-Loss of Heterozygosity,
pubmed-meshheading:12545169-Mutation,
pubmed-meshheading:12545169-Neoplasms, Squamous Cell,
pubmed-meshheading:12545169-Proteins,
pubmed-meshheading:12545169-Quantitative Trait Loci,
pubmed-meshheading:12545169-Reference Values,
pubmed-meshheading:12545169-Sequence Analysis, DNA,
pubmed-meshheading:12545169-Tumor Suppressor Proteins
|
| pubmed:year |
2003
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| pubmed:articleTitle |
An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma.
|
| pubmed:affiliation |
Department of Medicine, Division of Gastroenterology and Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore 21201, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|