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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-1-24
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pubmed:abstractText |
Transfusion of stored packed red blood cells (PRBCs) has unintended effects beyond the desired results of increased oxygen delivery. A particular concern is the potential for lipid and cytokine mediators present in PRBCs to augment the postinjury inflammatory response that sometimes culminates in multiple organ failure. Through the use of a polymerized human hemoglobin (PolyHeme), we have been able to measure the inflammatory response in patients resuscitated with minimal exposure to banked components in the early postinjury period.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-5282
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
133-9; discussion 139-40
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12544908-Adult,
pubmed-meshheading:12544908-Biological Markers,
pubmed-meshheading:12544908-Cell Adhesion Molecules,
pubmed-meshheading:12544908-E-Selectin,
pubmed-meshheading:12544908-Endothelium, Vascular,
pubmed-meshheading:12544908-Erythrocyte Transfusion,
pubmed-meshheading:12544908-Hemoglobins,
pubmed-meshheading:12544908-Humans,
pubmed-meshheading:12544908-Injury Severity Score,
pubmed-meshheading:12544908-Interleukin-10,
pubmed-meshheading:12544908-Interleukin-11,
pubmed-meshheading:12544908-Interleukin-6,
pubmed-meshheading:12544908-Interleukin-8,
pubmed-meshheading:12544908-Multiple Organ Failure,
pubmed-meshheading:12544908-Multiple Trauma,
pubmed-meshheading:12544908-Prospective Studies,
pubmed-meshheading:12544908-Resuscitation,
pubmed-meshheading:12544908-Risk Factors,
pubmed-meshheading:12544908-Treatment Outcome
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pubmed:year |
2003
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pubmed:articleTitle |
Alteration of the postinjury hyperinflammatory response by means of resuscitation with a red cell substitute.
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pubmed:affiliation |
Department of Surgery, Denver Health Medical Center, 777 Bannock Street, Denver, CO 80204, USA. jeff.johnson@dhha.org
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Controlled Clinical Trial
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