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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1976-6-2
|
| pubmed:abstractText |
Adenine arabinoside monophosphate (Ara-AMP) demonstrated antiviral activity equivalent to adenine arabinoside (Ara-A) against herpesvirus Types 1 and 2 in tissue culture. Against established herpes virus Type 1 epithelial keratitis in rabbits, Ara-AMP 2 per cent was comparable in efficacy to Ara-A 3 per cent, and Ara-AMP 20 per cent was superior to Ara-A 3 per cent. These results are especially significant in that Ara-A's high solubility will permit (1) more concentrated formulations to be presented topically and (2) adequate absorption by parenteral routes with smaller fluid loads than required for Ara-A.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0020-9988
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
196-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1254407-Adenosine Monophosphate,
pubmed-meshheading:1254407-Administration, Topical,
pubmed-meshheading:1254407-Animals,
pubmed-meshheading:1254407-Cytopathogenic Effect, Viral,
pubmed-meshheading:1254407-Dose-Response Relationship, Drug,
pubmed-meshheading:1254407-Drug Evaluation, Preclinical,
pubmed-meshheading:1254407-Herpesviridae,
pubmed-meshheading:1254407-Keratitis, Dendritic,
pubmed-meshheading:1254407-Purine Nucleosides,
pubmed-meshheading:1254407-Rabbits,
pubmed-meshheading:1254407-Vidarabine
|
| pubmed:year |
1976
|
| pubmed:articleTitle |
Anti-herpes activity of adenine arabinoside monophosphate.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|