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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-1-24
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pubmed:abstractText |
An inflammatory process may be one of the critical factors that contribute to the development of diabetic nephropathy (DN). We reported previously that intercellular adhesion molecule-1 (ICAM-1) is up-regulated and promotes macrophage infiltration in the glomeruli of diabetic rats. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have recently been emphasized to have anti-inflammatory effects; inhibition of leukocyte adhesion and migration, independent of the cholesterol-lowering effect. The present study was designed to test the hypothesis that statins prevent the development of DN by pleiotropic effects.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0931-0509
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
265-72
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12543879-Animals,
pubmed-meshheading:12543879-Anti-Inflammatory Agents,
pubmed-meshheading:12543879-Cell Movement,
pubmed-meshheading:12543879-Deoxyguanosine,
pubmed-meshheading:12543879-Diabetes Mellitus, Experimental,
pubmed-meshheading:12543879-Diabetic Nephropathies,
pubmed-meshheading:12543879-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:12543879-Intercellular Adhesion Molecule-1,
pubmed-meshheading:12543879-Kidney,
pubmed-meshheading:12543879-Kidney Glomerulus,
pubmed-meshheading:12543879-Macrophages,
pubmed-meshheading:12543879-Male,
pubmed-meshheading:12543879-NF-kappa B,
pubmed-meshheading:12543879-Oxidative Stress,
pubmed-meshheading:12543879-Pyridines,
pubmed-meshheading:12543879-Rats,
pubmed-meshheading:12543879-Rats, Sprague-Dawley,
pubmed-meshheading:12543879-Tissue Distribution
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pubmed:year |
2003
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pubmed:articleTitle |
HMG-CoA reductase inhibitor ameliorates diabetic nephropathy by its pleiotropic effects in rats.
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pubmed:affiliation |
Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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