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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2003-6-5
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pubmed:abstractText |
Coupling of ovalbumin (OVA) to anti-DEC-205 monoclonal antibody (mAb) (alphaDEC) induced the proliferation of OVA-specific T cells in vivo. Expansion was short-lived, caused by dendritic cells (DCs), and rendered T cells anergic thereafter. Phenotypic analysis revealed the induction of CD25+/CTLA-4+ T cells suppressing proliferation and interleukin-2 (IL-2) production of effector CD4+ T cells. The findings were supported by 2 disease models: (1) CD4+ T-cell-mediated hypersensitivity reactions were suppressed by the injection of alphaDEC-OVA and (2) the application of hapten-coupled alphaDEC-205 reduced CD8+ T-cell-mediated allergic reactions. Thus, targeting of antigens to immature DCs through alphaDEC antibodies led to the induction of regulatory T cells, providing the basis for novel strategies to induce regulatory T cells in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Haptens,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Ovalbumin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4862-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12543858-Animals,
pubmed-meshheading:12543858-Antibodies, Monoclonal,
pubmed-meshheading:12543858-Antigen Presentation,
pubmed-meshheading:12543858-Antigens,
pubmed-meshheading:12543858-Antigens, CD,
pubmed-meshheading:12543858-Antigens, Differentiation,
pubmed-meshheading:12543858-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12543858-CD8-Positive T-Lymphocytes,
pubmed-meshheading:12543858-CTLA-4 Antigen,
pubmed-meshheading:12543858-Dendritic Cells,
pubmed-meshheading:12543858-Dermatitis, Contact,
pubmed-meshheading:12543858-Haptens,
pubmed-meshheading:12543858-Hypersensitivity,
pubmed-meshheading:12543858-Hypersensitivity, Delayed,
pubmed-meshheading:12543858-Interleukin-2,
pubmed-meshheading:12543858-Lymphocyte Activation,
pubmed-meshheading:12543858-Lymphocyte Count,
pubmed-meshheading:12543858-Mice,
pubmed-meshheading:12543858-Mice, Inbred BALB C,
pubmed-meshheading:12543858-Ovalbumin,
pubmed-meshheading:12543858-Receptors, Interleukin-2,
pubmed-meshheading:12543858-T-Lymphocytes
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pubmed:year |
2003
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pubmed:articleTitle |
Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells.
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pubmed:affiliation |
Department of Dermatology, University of Mainz, Germany. mahnke@hautklinik.klinik.uni-mainz.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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