Source:http://linkedlifedata.com/resource/pubmed/id/12543220
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2003-1-24
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pubmed:abstractText |
The development of tolerance to therapeutic effects of antiepileptic drugs can be a problem in the treatment of epilepsy, bipolar disorder, and pain syndromes. In the present study, acute treatment with the new antiepileptic drug lamotrigine (LTG, 15 mg/kg) markedly suppressed seizure stage and seizure duration in amygdala-kindled rats; but this antiseizure effect was rapidly lost following 4-8 days of repeated treatment. When gabapentin (GBP, 20 mg/kg) was coadministered with LTG, the ability of LTG to suppress seizure stage, seizure duration, and after-discharge (AD) duration was markedly extended. In addition, GBP coadministration with LTG decreased the number of animals that developed LTG-related running fits (Stage 6 seizures) and lengthened the number of days required to develop running fits or complete tolerance. Neither acute nor repeated treatment with MK-801 (0.3 mg/kg), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, had effects on kindled seizures. However, cotreatment with MK-801 markedly extended the anticonvulsant effects of LTG on the three seizure indices and reduced running fits. These data indicate that cotreatment with either GBP or MK-801 slows tolerance development to the anticonvulsant effects of LTG on kindled seizures. Therapeutic implications of the present study remain to be explored.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Amines,
http://linkedlifedata.com/resource/pubmed/chemical/Anticonvulsants,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclohexanecarboxylic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Dizocilpine Maleate,
http://linkedlifedata.com/resource/pubmed/chemical/Triazines,
http://linkedlifedata.com/resource/pubmed/chemical/gabapentin,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/lamotrigine
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0091-3057
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
565-71
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12543220-Acetic Acids,
pubmed-meshheading:12543220-Amines,
pubmed-meshheading:12543220-Animals,
pubmed-meshheading:12543220-Anticonvulsants,
pubmed-meshheading:12543220-Cyclohexanecarboxylic Acids,
pubmed-meshheading:12543220-Dizocilpine Maleate,
pubmed-meshheading:12543220-Drug Therapy, Combination,
pubmed-meshheading:12543220-Drug Tolerance,
pubmed-meshheading:12543220-Kindling, Neurologic,
pubmed-meshheading:12543220-Male,
pubmed-meshheading:12543220-Rats,
pubmed-meshheading:12543220-Rats, Sprague-Dawley,
pubmed-meshheading:12543220-Seizures,
pubmed-meshheading:12543220-Triazines,
pubmed-meshheading:12543220-gamma-Aminobutyric Acid
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pubmed:year |
2003
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pubmed:articleTitle |
Coadministration of gabapentin or MK-801 with lamotrigine slows tolerance to its anticonvulsant effects on kindled seizures.
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pubmed:affiliation |
Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA. zzhang1@usuhs.mil
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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