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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-1-24
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pubmed:abstractText |
The macrocyclic lathyrane polyester Euphorbia factor L10 (1a) has been obtained from the seeds of the caper spurge (E. lathyris). The interaction of L10 (1a) and its acetyl derivative (1b) with P-glycoprotein, a multidrug transporter overexpressed in cancer cells and responsible for resistance to chemotherapy, was investigated. The results established lathyrane diterpenoids as a novel chemotype for P-glycoprotein inhibitors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0163-3864
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
140-2
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12542364-Diterpenes,
pubmed-meshheading:12542364-Drug Resistance, Multiple,
pubmed-meshheading:12542364-Drug Resistance, Neoplasm,
pubmed-meshheading:12542364-Drug Screening Assays, Antitumor,
pubmed-meshheading:12542364-Euphorbia,
pubmed-meshheading:12542364-Germany,
pubmed-meshheading:12542364-Humans,
pubmed-meshheading:12542364-K562 Cells,
pubmed-meshheading:12542364-Leukemia,
pubmed-meshheading:12542364-Molecular Structure,
pubmed-meshheading:12542364-P-Glycoprotein,
pubmed-meshheading:12542364-Plants, Medicinal,
pubmed-meshheading:12542364-Seeds,
pubmed-meshheading:12542364-Tumor Cells, Cultured
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pubmed:year |
2003
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pubmed:articleTitle |
A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris).
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pubmed:affiliation |
Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Viale Ferrucci 33, 28100 Novara, Italy. appendino@pharm.unipmn.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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