Source:http://linkedlifedata.com/resource/pubmed/id/12540618
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2003-1-23
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| pubmed:abstractText |
Glucose and palmitate metabolism and contractile function were measured with ex vivo perfused working hearts from control (db/+) and diabetic (db/db) female mice at 6, 10-12, and 16-18 weeks of age. Palmitate oxidation was increased by 2.2-fold in 6-week-old db/db hearts and remained elevated in 10- to 12- and 16- to 18-week-old hearts. Carbohydrate oxidation was normal at 6 weeks but was reduced to 27 and 23% of control at 10-12 and 16-18 weeks, respectively. At 6 weeks, db/db hearts exhibited a slight reduction in mechanical function, whereas marked signs of dysfunction were evident at 10-12 and 16-18 weeks. Mechanical function after ischemia-reperfusion was examined in hearts from male mice; at 6 weeks, db/db hearts showed normal recovery, whereas at 12 weeks it was markedly reduced. Fatty acid oxidation was the predominant substrate used after reperfusion. Thus, diabetic db/db hearts exhibit signs of a progressive cardiomyopathy; increased fatty acid oxidation preceded reductions in carbohydrate oxidation. Postischemic recovery of function was reduced in db/db hearts, in parallel with age-dependent changes in normoxic contractile performance. Finally, peroxisome proliferator-activated receptor-alpha treatment (3 weeks) did not affect sensitivity to ischemia-reperfusion, even though carbohydrate oxidation was increased and palmitate oxidation was decreased.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
0012-1797
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
52
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
434-41
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12540618-Aging,
pubmed-meshheading:12540618-Animals,
pubmed-meshheading:12540618-Blood Glucose,
pubmed-meshheading:12540618-Body Weight,
pubmed-meshheading:12540618-Carbohydrate Metabolism,
pubmed-meshheading:12540618-Diabetes Mellitus, Type 2,
pubmed-meshheading:12540618-Fatty Acids, Nonesterified,
pubmed-meshheading:12540618-Female,
pubmed-meshheading:12540618-Heart,
pubmed-meshheading:12540618-Hemodynamics,
pubmed-meshheading:12540618-Insulin,
pubmed-meshheading:12540618-Mice,
pubmed-meshheading:12540618-Mice, Inbred C57BL,
pubmed-meshheading:12540618-Mice, Mutant Strains,
pubmed-meshheading:12540618-Myocardial Contraction,
pubmed-meshheading:12540618-Myocardial Ischemia,
pubmed-meshheading:12540618-Myocardium,
pubmed-meshheading:12540618-Organ Size,
pubmed-meshheading:12540618-Oxidation-Reduction
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice.
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| pubmed:affiliation |
Department of Medical Physiology, Faculty of Medicine, University of Tromsoe, Norway. ellenaa@fagmed.uit.no
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| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|