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12540232
Source:
http://linkedlifedata.com/resource/pubmed/id/12540232
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rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0243077
,
umls-concept:C1120843
,
umls-concept:C1366876
pubmed:issue
3
pubmed:dateCreated
2003-1-23
pubmed:abstractText
Imidazo[1,2-a]pyridyl N-arylpyridazinones were hybridized from the classic pyridinylimidazoles and the more recent dual hydrogen bond acceptors, resulting in a new structural class of selective p38 MAP kinase inhibitors.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9716531
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors
,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases
,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridazines
,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-2623
pubmed:author
pubmed-author:ChoiBernard KBK
,
pubmed-author:CollettiSteven LSL
,
pubmed-author:DixonElizabeth CEC
,
pubmed-author:DohertyJames BJB
,
pubmed-author:FitzgeraldCatherine ECE
,
pubmed-author:FrieJessica LJL
,
pubmed-author:KumarSanjeevS
,
pubmed-author:NicholsElizabeth AEA
,
pubmed-author:O'KeefeStephen JSJ
,
pubmed-author:O'NeillEdward AEA
,
pubmed-author:PorterGeneG
,
pubmed-author:SamuelKopparaK
,
pubmed-author:ScapinGiovannaG
,
pubmed-author:SchmatzDennis MDM
,
pubmed-author:SchwartzCheryl DCD
,
pubmed-author:ShoopWesley LWL
,
pubmed-author:SinghSuresh BSB
,
pubmed-author:ThompsonChris MCM
,
pubmed-author:ThompsonJames EJE
,
pubmed-author:WangRuixiuR
,
pubmed-author:WoodsAndreaA
,
pubmed-author:ZallerDennis MDM
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
349-52
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:12540232-Animals
,
pubmed-meshheading:12540232-Enzyme Inhibitors
,
pubmed-meshheading:12540232-Mice
,
pubmed-meshheading:12540232-Mitogen-Activated Protein Kinases
,
pubmed-meshheading:12540232-Models, Molecular
,
pubmed-meshheading:12540232-Pyridazines
,
pubmed-meshheading:12540232-Structure-Activity Relationship
,
pubmed-meshheading:12540232-p38 Mitogen-Activated Protein Kinases
pubmed:year
2003
pubmed:articleTitle
Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones.
pubmed:affiliation
Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey 07065, USA. steve_colletti@merck.com
pubmed:publicationType
Journal Article