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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-1-22
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pubmed:abstractText |
The first tissue-specific angiogenic molecule, endocrine gland-derived vascular endothelial growth factor (EG-VEGF), was identified recently in human ovary, raising hopes of developing tumor type-specific angiogenesis inhibitors. In the present study, we analyzed the expression of EG-VEGF mRNA in normal human tissues and ovarian neoplasms by quantitative real-time reverse transcription-PCR. EG-VEGF mRNA was expressed in all ovarian neoplasms examined. No significant difference was identified among benign, low malignant potential neoplasms or stage I ovarian cancer, all of which exhibited 2-fold lower mRNA levels compared with normal premenopausal ovaries. EG-VEGF mRNA levels further decreased in late stage compared with early stage carcinomas (P < 0.05) and were consistently lower in laser capture microdissected tumor islets compared with surrounding stroma. EG-VEGF was undetectable by reverse transcription-PCR in 17 established epithelial ovarian cancer cell lines or in cultured human ovarian surface epithelial cells, whereas it was detected in peripheral blood as well as tumor-infiltrating T lymphocytes. Finally, in contrast to VEGF, EG-VEGF mRNA levels did not correlate with clinical outcome in advanced ovarian carcinoma. These results suggest that EG-VEGF is most likely derived from nonepithelial components of ovarian carcinomas and may play a marginal role in promoting angiogenesis in advanced ovarian carcinoma. We postulate that EG-VEGF-targeted antiangiogenic therapy may prove useful in early stage but not in advanced stage ovarian carcinoma.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiogenesis Inducing Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelial Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Gastrointestinal Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/PROK1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:Conejo-GarciaJose-RamonJR,
pubmed-author:CoukosGeorgeG,
pubmed-author:FracchioliStefanoS,
pubmed-author:KatsarosDionyssiosD,
pubmed-author:LevineBruceB,
pubmed-author:Mohamed-HadleyAlishaA,
pubmed-author:RubinStephen CSC,
pubmed-author:SchliengerKatiaK,
pubmed-author:TollAlannaA,
pubmed-author:YangNuoN,
pubmed-author:ZhangLinL
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
264-72
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12538479-Angiogenesis Inducing Agents,
pubmed-meshheading:12538479-Carcinoma,
pubmed-meshheading:12538479-Endocrine Glands,
pubmed-meshheading:12538479-Endothelial Growth Factors,
pubmed-meshheading:12538479-Female,
pubmed-meshheading:12538479-Flow Cytometry,
pubmed-meshheading:12538479-Gastrointestinal Hormones,
pubmed-meshheading:12538479-Humans,
pubmed-meshheading:12538479-Immunohistochemistry,
pubmed-meshheading:12538479-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:12538479-Lasers,
pubmed-meshheading:12538479-Lymphokines,
pubmed-meshheading:12538479-Microscopy, Fluorescence,
pubmed-meshheading:12538479-Ovarian Neoplasms,
pubmed-meshheading:12538479-RNA, Messenger,
pubmed-meshheading:12538479-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12538479-Time Factors,
pubmed-meshheading:12538479-Tissue Distribution,
pubmed-meshheading:12538479-Treatment Outcome,
pubmed-meshheading:12538479-Tumor Cells, Cultured,
pubmed-meshheading:12538479-Vascular Endothelial Growth Factor, Endocrine-Gland-Derived,
pubmed-meshheading:12538479-Vascular Endothelial Growth Factor A,
pubmed-meshheading:12538479-Vascular Endothelial Growth Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Expression of endocrine gland-derived vascular endothelial growth factor in ovarian carcinoma.
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pubmed:affiliation |
Center for Research on Reproduction and Women's Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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