Source:http://linkedlifedata.com/resource/pubmed/id/12537859
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2003-3-4
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| pubmed:abstractText |
In studies on the Finnish Twin Cohort, we investigate genetic and environmental determinants of common, complex diseases, and their behavioral risk factors in Finland, a genetically unique and culturally homogenous population. We have formed the following databases: 1) Like-sexed twin pairs (13,888 pairs of known zygosity) form the older Twin Cohort. They have participated since 1975 in mail surveys, in clinical examinations for subsamples, and have been followed-up for morbidity using national medical registers; 2) The older Twin Cohort was expanded in 1996 to include opposite-sex pairs born 1938-1957 (c. 8000 pairs); 3) Two, new longitudinal studies of adolescent twins and their families, form a complementary, ongoing study base described in more detail in an accompanying article. Genetic and environmental effects vary over the life-span, and only longitudinal studies in genetically informative data sets permits the evaluation of such effects. Finally, the inclusion of DNA-based genetic information in a phenotypically rich family data base will offer a unique resource for research in genetic epidemiology and behavioral medicine.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
1369-0523
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
5
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
358-65
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:12537859-Adolescent,
pubmed-meshheading:12537859-Adult,
pubmed-meshheading:12537859-Age Distribution,
pubmed-meshheading:12537859-Aged,
pubmed-meshheading:12537859-Cohort Studies,
pubmed-meshheading:12537859-Databases, Factual,
pubmed-meshheading:12537859-Diseases in Twins,
pubmed-meshheading:12537859-Environment,
pubmed-meshheading:12537859-Female,
pubmed-meshheading:12537859-Finland,
pubmed-meshheading:12537859-Gene Library,
pubmed-meshheading:12537859-Genetic Predisposition to Disease,
pubmed-meshheading:12537859-Humans,
pubmed-meshheading:12537859-Male,
pubmed-meshheading:12537859-Middle Aged,
pubmed-meshheading:12537859-Molecular Epidemiology,
pubmed-meshheading:12537859-Morbidity,
pubmed-meshheading:12537859-Questionnaires,
pubmed-meshheading:12537859-Registries,
pubmed-meshheading:12537859-Risk Factors,
pubmed-meshheading:12537859-Sex Distribution,
pubmed-meshheading:12537859-Twin Studies as Topic
|
| pubmed:year |
2002
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| pubmed:articleTitle |
Genetic and environmental factors in complex diseases: the older Finnish Twin Cohort.
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| pubmed:affiliation |
Dept. of Public Health, University of Helsinki, National Public Health Institute, Helsinki, Finland. jaakko.kaprio@helsinki.fi
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, Non-U.S. Gov't
|