12534643

Source:http://linkedlifedata.com/resource/pubmed/id/12534643

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0010763, umls-concept:C0011849, umls-concept:C0086418, umls-concept:C0441655, umls-concept:C0442805, umls-concept:C1515655
pubmed:issue	1
pubmed:dateCreated	2003-1-21
pubmed:abstractText	Cytochrome P450 2E1 (CYP2E1) is thought to activate a number of protoxins, and has been implicated in the development of liver disease. Increased hepatic expression of CYP2E1 occurs in rat models of diabetes but it is unclear whether human diabetics display a similar up-regulation. This study was designed to test the hypothesis that human diabetics experience enhanced CYP2E1 expression.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/M01-RR00750, http://linkedlifedata.com/resource/pubmed/grant/T32GM08425
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7503323
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Chlorzoxazone, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP2E1, http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary, http://linkedlifedata.com/resource/pubmed/chemical/RNA
pubmed:status	MEDLINE
pubmed:month	Jan
pubmed:issn	0306-5251
pubmed:author	pubmed-author:AsgharAliA, pubmed-author:GorskiJ CJC, pubmed-author:HallStephen DSD, pubmed-author:LiLangL, pubmed-author:MayaJuan FJF, pubmed-author:WangZaiqiZ
pubmed:issnType	Print
pubmed:volume	55
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	77-85
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:12534643-Adolescent, pubmed-meshheading:12534643-Adult, pubmed-meshheading:12534643-Aged, pubmed-meshheading:12534643-Chlorzoxazone, pubmed-meshheading:12534643-Cytochrome P-450 CYP2E1, pubmed-meshheading:12534643-DNA, Complementary, pubmed-meshheading:12534643-Diabetes Mellitus, Type 1, pubmed-meshheading:12534643-Diabetes Mellitus, Type 2, pubmed-meshheading:12534643-Female, pubmed-meshheading:12534643-Humans, pubmed-meshheading:12534643-Male, pubmed-meshheading:12534643-Middle Aged, pubmed-meshheading:12534643-RNA
pubmed:year	2003
pubmed:articleTitle	Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans.
pubmed:affiliation	Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Wishard Memorial Hospital, OPW 320, Indianapolis IN, USA.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't