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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
Pt 1
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pubmed:dateCreated |
2003-1-20
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pubmed:abstractText |
Using synthetic peptides we have shown that positively charged sequences present at the C terminus of the L1 protein and the N and C termini of the L2 protein of human papillomavirus type 16 (HPV-16) bind to both DNA and heparan sulfate receptors. Moreover, these short amino acid sequences are sufficient to mediate gene transfer in COS-7 cells. The L1 proteins of other HPVs were shown to contain one or two DNA- and heparin-binding sequences that have the capacity to transfer genes. These DNA-binding sequences also recognized the enhancing packaging sequence of bovine papillomavirus type 1. The results suggest that the L2 protein could participate in DNA packaging during maturation of virions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Capsid Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Heparitin Sulfate,
http://linkedlifedata.com/resource/pubmed/chemical/L1 protein, Human papillomavirus...,
http://linkedlifedata.com/resource/pubmed/chemical/L2 protein, Human papillomavirus...,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1317
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
157-64
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12533712-Amino Acid Sequence,
pubmed-meshheading:12533712-Animals,
pubmed-meshheading:12533712-COS Cells,
pubmed-meshheading:12533712-Capsid,
pubmed-meshheading:12533712-Capsid Proteins,
pubmed-meshheading:12533712-DNA-Binding Proteins,
pubmed-meshheading:12533712-Gene Transfer Techniques,
pubmed-meshheading:12533712-Genetic Vectors,
pubmed-meshheading:12533712-Heparitin Sulfate,
pubmed-meshheading:12533712-Humans,
pubmed-meshheading:12533712-Molecular Sequence Data,
pubmed-meshheading:12533712-Oncogene Proteins, Viral,
pubmed-meshheading:12533712-Papillomaviridae,
pubmed-meshheading:12533712-Peptides,
pubmed-meshheading:12533712-Receptors, Cell Surface,
pubmed-meshheading:12533712-Structure-Activity Relationship,
pubmed-meshheading:12533712-Transfection,
pubmed-meshheading:12533712-Virion
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pubmed:year |
2003
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pubmed:articleTitle |
Positively charged sequences of human papillomavirus type 16 capsid proteins are sufficient to mediate gene transfer into target cells via the heparan sulfate receptor.
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pubmed:affiliation |
Laboratoire de Virologie Moléculaire, INSERM EMIU 00-10 and USC INRA, Faculté des Sciences Pharmaceutiques 'Philippe Maupas', 31 avenue Monge, 37200 Tours, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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