Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-1-20
pubmed:abstractText
Haploinsufficiency of Tbx1 is likely a major determinant of cardiac and craniofacial birth defects associated with DiGeorge syndrome. Although mice deficient in Tbx1 exhibit pharyngeal and aortic arch defects, the developmental program and mechanisms through which Tbx1 functions are relatively unknown. We identified a single cis-element upstream of Tbx1 that recognized winged helix/forkhead box (Fox)-containing transcription factors and was essential for regulation of Tbx1 transcription in the pharyngeal endoderm and head mesenchyme. The Tbx1 regulatory region was responsive to signaling by Sonic hedgehog (Shh) in vivo. We show that Shh is necessary for aortic arch development, similar to Tbx1, and is also required for expression of Foxa2 and Foxc2 in the pharyngeal endoderm and head mesenchyme, respectively. Foxa2, Foxc1, or Foxc2 could bind and activate transcription through the critical cis-element upstream of Tbx1, and Foxc proteins were required, within their expression domains, for Tbx1 transcription in vivo. We propose that Tbx1 is a direct transcriptional target of Fox proteins and that Fox proteins may serve an intermediary role in Shh regulation of Tbx1.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-10203826, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-10479458, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-10517636, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-10660040, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-10675351, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-10702024, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-10835639, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-11005797, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-11078474, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-11239417, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-11242049, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-11242110, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-11412027, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-11562355, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-11598952, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-11688566, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-11702954, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-11715041, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-11783996, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-11784028, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-11823633, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-11864602, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-11971873, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-12125909, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-12223415, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-12223416, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-12223417, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-2557196, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-7614707, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-7819424, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-7920656, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-8069909, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-8069910, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-8532532, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-8817449, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-8837770, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-8853987, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-9096345, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-9106663, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-9118802, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-9204763, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-9224671, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-9409679, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-9463325, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-9504043, http://linkedlifedata.com/resource/pubmed/commentcorrection/12533514-9635428
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/FOXA2 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/FOXC1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/Foxa2 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Foxc1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Hedgehog Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Nuclear Factor 3-beta, http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins, http://linkedlifedata.com/resource/pubmed/chemical/SHH protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Shh protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/T-Box Domain Proteins, http://linkedlifedata.com/resource/pubmed/chemical/TBX1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Tbx1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/mesenchyme fork head 1 protein
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0890-9369
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
269-81
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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