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rdf:type |
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lifeskim:mentions |
umls-concept:C0002395,
umls-concept:C0006104,
umls-concept:C0021920,
umls-concept:C0035647,
umls-concept:C0205217,
umls-concept:C0332281,
umls-concept:C0769789,
umls-concept:C1413885,
umls-concept:C1550025,
umls-concept:C1720655,
umls-concept:C1882417,
umls-concept:C1947974,
umls-concept:C2247257,
umls-concept:C2346689,
umls-concept:C2353566,
umls-concept:C2700455
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pubmed:issue |
1
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pubmed:dateCreated |
2003-1-20
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pubmed:abstractText |
CYP46, the gene encoding cholesterol 24-hydroxylase, plays a key role in the hydroxylation of cholesterol and thereby mediates its removal from brain.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0003-9942
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pubmed:author |
pubmed-author:BenussiLuisaL,
pubmed-author:BinettiGiulianoG,
pubmed-author:BrühlAnnetteA,
pubmed-author:BraakHeikoH,
pubmed-author:GhebremedhinEstifanosE,
pubmed-author:HegiThomasT,
pubmed-author:HockChristophC,
pubmed-author:IakovidouVassilikiV,
pubmed-author:LütjohannDieterD,
pubmed-author:MaddalenaAlessiaA,
pubmed-author:NicosiaFrancescaF,
pubmed-author:NitschRoger MRM,
pubmed-author:PapassotiropoulosAndreasA,
pubmed-author:PaschThomasT,
pubmed-author:SchmidSimonS,
pubmed-author:StrefferJohannes RJR,
pubmed-author:ThalDietmarD,
pubmed-author:TräxlerMurielM,
pubmed-author:TsolakiMagdaliniM
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
29-35
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12533085-Age of Onset,
pubmed-meshheading:12533085-Aged,
pubmed-meshheading:12533085-Aged, 80 and over,
pubmed-meshheading:12533085-Alzheimer Disease,
pubmed-meshheading:12533085-Amyloid beta-Peptides,
pubmed-meshheading:12533085-Brain,
pubmed-meshheading:12533085-Cholesterol,
pubmed-meshheading:12533085-Female,
pubmed-meshheading:12533085-Genetic Predisposition to Disease,
pubmed-meshheading:12533085-Genotype,
pubmed-meshheading:12533085-Humans,
pubmed-meshheading:12533085-Hydroxycholesterols,
pubmed-meshheading:12533085-Introns,
pubmed-meshheading:12533085-Male,
pubmed-meshheading:12533085-Peptide Fragments,
pubmed-meshheading:12533085-Phosphorylation,
pubmed-meshheading:12533085-Polymorphism, Genetic,
pubmed-meshheading:12533085-Risk Factors,
pubmed-meshheading:12533085-Steroid Hydroxylases,
pubmed-meshheading:12533085-tau Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism.
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pubmed:affiliation |
Division of Pychiatry Research, University of Zurich, Switzerland. papas@bli.unizh.ch
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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