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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5609
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pubmed:dateCreated |
2003-2-14
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pubmed:abstractText |
Toll-like receptors (TLRs) control activation of adaptive immune responses by antigen-presenting cells (APCs). However, initiation of adaptive immune responses is also controlled by regulatory T cells (TR cells), which act to prevent activation of autoreactive T cells. Here we describe a second mechanism of immune induction by TLRs, which is independent of effects on costimulation. Microbial induction of the Toll pathway blocked the suppressive effect of CD4+CD25+ TR cells, allowing activation of pathogen-specific adaptive immune responses. This block of suppressor activity was dependent in part on interleukin-6, which was induced by TLRs upon recognition of microbial products.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Conditioned,
http://linkedlifedata.com/resource/pubmed/chemical/Dinucleoside Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Myd88 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloid Differentiation Factor 88,
http://linkedlifedata.com/resource/pubmed/chemical/Ovalbumin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/cytidylyl-3'-5'-guanosine
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
14
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pubmed:volume |
299
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1033-6
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:12532024-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:12532024-Animals,
pubmed-meshheading:12532024-Antigens, CD,
pubmed-meshheading:12532024-Antigens, Differentiation,
pubmed-meshheading:12532024-Cells, Cultured,
pubmed-meshheading:12532024-Culture Media, Conditioned,
pubmed-meshheading:12532024-Dendritic Cells,
pubmed-meshheading:12532024-Dinucleoside Phosphates,
pubmed-meshheading:12532024-Drosophila Proteins,
pubmed-meshheading:12532024-Immune Tolerance,
pubmed-meshheading:12532024-Immunization,
pubmed-meshheading:12532024-Interleukin-6,
pubmed-meshheading:12532024-Lipopolysaccharides,
pubmed-meshheading:12532024-Lymphocyte Activation,
pubmed-meshheading:12532024-Membrane Glycoproteins,
pubmed-meshheading:12532024-Mice,
pubmed-meshheading:12532024-Mice, Inbred C57BL,
pubmed-meshheading:12532024-Myeloid Differentiation Factor 88,
pubmed-meshheading:12532024-Ovalbumin,
pubmed-meshheading:12532024-Receptors, Cell Surface,
pubmed-meshheading:12532024-Receptors, Immunologic,
pubmed-meshheading:12532024-Self Tolerance,
pubmed-meshheading:12532024-T-Lymphocytes,
pubmed-meshheading:12532024-T-Lymphocytes, Regulatory,
pubmed-meshheading:12532024-Toll-Like Receptors
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pubmed:year |
2003
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pubmed:articleTitle |
Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells.
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pubmed:affiliation |
Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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