|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1-2
|
|
pubmed:dateCreated |
2003-1-17
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
To help understand the biological functions of carbonic anhydrase-related proteins (CA-RPs VIII, X, and XI), we obtained cDNA clones of murine CA-RPs X and XI and studied the tissue distribution of all three CA-RPs and their developmental expression in the murine embryonic brain. The amino acid sequences of murine CA-RPs are highly conserved with their human homologues, indicating a fundamental biological role of CA-RPs. Among a panel of vital organs, the strongest mRNA expression of all three CA-RPs was consistently observed in the brain. Immunohistochemical analysis revealed the expression of all three CA-RPs in the neural cell body and neurites. CA-RP X was also observed in the myelin sheath, as demonstrated using the shiverer demyelinated mouse. In murine embryos, CA-RP VIII and X messages first appeared in the middle of the gestation period, while the CA-RP XI message was seen at an early gestational stage and expressed to a lesser extent as gestation progressed. All CA-RPs were expressed in the neuroprogenitor cells in the subventricular area and subsequently detected in the neural cells migrating to the cortex. Although the exact function of CA-RPs is still undefined, these findings suggest an important role of CA-RPs in the CNS.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/CA10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CA11 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CA8 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Car10 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Car11 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Car8 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Carbonic Anhydrases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0169-328X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
30
|
|
pubmed:volume |
109
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
207-15
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:12531530-Animals,
pubmed-meshheading:12531530-Antibodies, Monoclonal,
pubmed-meshheading:12531530-Brain,
pubmed-meshheading:12531530-Carbonic Anhydrases,
pubmed-meshheading:12531530-Cloning, Molecular,
pubmed-meshheading:12531530-DNA, Complementary,
pubmed-meshheading:12531530-Embryo, Mammalian,
pubmed-meshheading:12531530-Female,
pubmed-meshheading:12531530-Gene Expression Regulation, Developmental,
pubmed-meshheading:12531530-Gestational Age,
pubmed-meshheading:12531530-Humans,
pubmed-meshheading:12531530-Immunohistochemistry,
pubmed-meshheading:12531530-Isoenzymes,
pubmed-meshheading:12531530-Mice,
pubmed-meshheading:12531530-Mice, Inbred BALB C,
pubmed-meshheading:12531530-Molecular Sequence Data,
pubmed-meshheading:12531530-Nerve Tissue Proteins,
pubmed-meshheading:12531530-Neurons,
pubmed-meshheading:12531530-Pregnancy,
pubmed-meshheading:12531530-Tissue Distribution,
pubmed-meshheading:12531530-Tumor Markers, Biological
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
cDNA cloning and developmental expression of murine carbonic anhydrase-related proteins VIII, X, and XI.
|
|
pubmed:affiliation |
First Department of Internal Medicine, Kochi Medical School, Nankoku, Kochi 783-8505, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
