Source:http://linkedlifedata.com/resource/pubmed/id/12530982
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2003-1-17
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pubmed:abstractText |
T cells expand without intentional antigen stimulation when transferred into adult lymphopenic environments. In this study, we show that the physiologic lymphopenic environment existing in neonatal mice also supports CD4 T cell proliferation. Strikingly, naive CD4 T cells that proliferate within neonates acquire the phenotypic and functional characteristics of memory cells. Such proliferation is inhibited by the presence of both memory and naive CD4 T cells, is enhanced by 3-day thymectomy, is independent of IL-7, and requires a class II MHC-TCR interaction and a CD28-mediated signal. CD44(bright) CD4 T cells in neonates have a wide repertoire as judged by the distribution of Vbeta expression. Thus, lymphopenia-induced T cell proliferation is a physiologic process that occurs during the early postnatal period.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1074-7613
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
131-40
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12530982-Animals,
pubmed-meshheading:12530982-Animals, Congenic,
pubmed-meshheading:12530982-Animals, Newborn,
pubmed-meshheading:12530982-Antigens, CD44,
pubmed-meshheading:12530982-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12530982-Cell Division,
pubmed-meshheading:12530982-Immunologic Memory,
pubmed-meshheading:12530982-Lymphocyte Activation,
pubmed-meshheading:12530982-Lymphopenia,
pubmed-meshheading:12530982-Major Histocompatibility Complex,
pubmed-meshheading:12530982-Mice,
pubmed-meshheading:12530982-Mice, Inbred C57BL,
pubmed-meshheading:12530982-Mice, Knockout,
pubmed-meshheading:12530982-Mice, Transgenic,
pubmed-meshheading:12530982-Receptors, Antigen, T-Cell,
pubmed-meshheading:12530982-Thymectomy
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pubmed:year |
2003
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pubmed:articleTitle |
Neonates support lymphopenia-induced proliferation.
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pubmed:affiliation |
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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