Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-1-16
pubmed:abstractText
Responses to human CGRP, adrenomedullin (ADM), and proadrenomedullin NH2-terminal 20 peptide (PAMP) were studied in small human thymic arteries. CGRP, ADM, and PAMP produced concentration-dependent vasodilator responses in arteries preconstricted with the thromboxane mimic U-46619. Responses to ADM and PAMP were attenuated, whereas responses to CGRP were not altered by endothelial denudation. Inhibitors of nitric oxide synthase and guanylyl cyclase attenuated responses to ADM and PAMP but not to CGRP. The CGRP1 receptor antagonist CGRP(8-37) attenuated responses to CGRP and ADM but not to PAMP. Responses to CGRP were reduced by SQ-22536 and Rp-cAMPS, inhibitors of adenylyl cyclase and PKA. These data suggest that responses to CGRP and ADM are mediated by CGRP(8-37)-sensitive receptors and that the endothelial ADM receptor induces vasodilation by a nitric oxide-guanylyl cyclase mechanism, whereas a smooth muscle CGRP receptor signals by a cAMP-dependent mechanism. A different endothelial receptor recognizes PAMP and signals by a nitric oxide-dependent mechanism.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/15-Hydroxy-11 alpha,9..., http://linkedlifedata.com/resource/pubmed/chemical/9-(tetrahydro-2-furyl)-adenine, http://linkedlifedata.com/resource/pubmed/chemical/Adenine, http://linkedlifedata.com/resource/pubmed/chemical/Adenylate Cyclase, http://linkedlifedata.com/resource/pubmed/chemical/Adrenomedullin, http://linkedlifedata.com/resource/pubmed/chemical/Calcitonin Gene-Related Peptide, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP, http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Cyclase, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase, http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments, http://linkedlifedata.com/resource/pubmed/chemical/Peptides, http://linkedlifedata.com/resource/pubmed/chemical/Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Calcitonin Gene-Related..., http://linkedlifedata.com/resource/pubmed/chemical/Thionucleotides, http://linkedlifedata.com/resource/pubmed/chemical/adenosine-3',5'-cyclic...
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0363-6119
pubmed:author
pubmed:issnType
Print
pubmed:volume
284
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R531-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:12529288-15-Hydroxy-11 alpha,9..., pubmed-meshheading:12529288-Adenine, pubmed-meshheading:12529288-Adenylate Cyclase, pubmed-meshheading:12529288-Adrenomedullin, pubmed-meshheading:12529288-Arteries, pubmed-meshheading:12529288-Calcitonin Gene-Related Peptide, pubmed-meshheading:12529288-Cyclic AMP, pubmed-meshheading:12529288-Dose-Response Relationship, Drug, pubmed-meshheading:12529288-Endothelium, Vascular, pubmed-meshheading:12529288-Guanylate Cyclase, pubmed-meshheading:12529288-Humans, pubmed-meshheading:12529288-Nitric Oxide, pubmed-meshheading:12529288-Nitric Oxide Synthase, pubmed-meshheading:12529288-Peptide Fragments, pubmed-meshheading:12529288-Peptides, pubmed-meshheading:12529288-Proteins, pubmed-meshheading:12529288-Receptors, Calcitonin Gene-Related Peptide, pubmed-meshheading:12529288-Thionucleotides, pubmed-meshheading:12529288-Thymus Gland, pubmed-meshheading:12529288-Vasodilation
pubmed:year
2003
pubmed:articleTitle
Responses to human CGRP, ADM, and PAMP in human thymic arteries.
pubmed:affiliation
Department of Pharmacology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't