rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-1-16
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pubmed:abstractText |
Responses to human CGRP, adrenomedullin (ADM), and proadrenomedullin NH2-terminal 20 peptide (PAMP) were studied in small human thymic arteries. CGRP, ADM, and PAMP produced concentration-dependent vasodilator responses in arteries preconstricted with the thromboxane mimic U-46619. Responses to ADM and PAMP were attenuated, whereas responses to CGRP were not altered by endothelial denudation. Inhibitors of nitric oxide synthase and guanylyl cyclase attenuated responses to ADM and PAMP but not to CGRP. The CGRP1 receptor antagonist CGRP(8-37) attenuated responses to CGRP and ADM but not to PAMP. Responses to CGRP were reduced by SQ-22536 and Rp-cAMPS, inhibitors of adenylyl cyclase and PKA. These data suggest that responses to CGRP and ADM are mediated by CGRP(8-37)-sensitive receptors and that the endothelial ADM receptor induces vasodilation by a nitric oxide-guanylyl cyclase mechanism, whereas a smooth muscle CGRP receptor signals by a cAMP-dependent mechanism. A different endothelial receptor recognizes PAMP and signals by a nitric oxide-dependent mechanism.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/15-Hydroxy-11 alpha,9...,
http://linkedlifedata.com/resource/pubmed/chemical/9-(tetrahydro-2-furyl)-adenine,
http://linkedlifedata.com/resource/pubmed/chemical/Adenine,
http://linkedlifedata.com/resource/pubmed/chemical/Adenylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenomedullin,
http://linkedlifedata.com/resource/pubmed/chemical/Calcitonin Gene-Related Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Calcitonin Gene-Related...,
http://linkedlifedata.com/resource/pubmed/chemical/Thionucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/adenosine-3',5'-cyclic...
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0363-6119
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
284
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R531-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12529288-15-Hydroxy-11 alpha,9...,
pubmed-meshheading:12529288-Adenine,
pubmed-meshheading:12529288-Adenylate Cyclase,
pubmed-meshheading:12529288-Adrenomedullin,
pubmed-meshheading:12529288-Arteries,
pubmed-meshheading:12529288-Calcitonin Gene-Related Peptide,
pubmed-meshheading:12529288-Cyclic AMP,
pubmed-meshheading:12529288-Dose-Response Relationship, Drug,
pubmed-meshheading:12529288-Endothelium, Vascular,
pubmed-meshheading:12529288-Guanylate Cyclase,
pubmed-meshheading:12529288-Humans,
pubmed-meshheading:12529288-Nitric Oxide,
pubmed-meshheading:12529288-Nitric Oxide Synthase,
pubmed-meshheading:12529288-Peptide Fragments,
pubmed-meshheading:12529288-Peptides,
pubmed-meshheading:12529288-Proteins,
pubmed-meshheading:12529288-Receptors, Calcitonin Gene-Related Peptide,
pubmed-meshheading:12529288-Thionucleotides,
pubmed-meshheading:12529288-Thymus Gland,
pubmed-meshheading:12529288-Vasodilation
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pubmed:year |
2003
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pubmed:articleTitle |
Responses to human CGRP, ADM, and PAMP in human thymic arteries.
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pubmed:affiliation |
Department of Pharmacology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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