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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-1-15
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pubmed:abstractText |
A blunted hypoxic ventilatory response (HVR) has been observed in some sufferers of high-altitude pulmonary edema (HAPE), and was proposed as a potential mechanism in its pathogenesis. Tyrosine hydroxylase (TH) is a rate-limiting enzyme in the carotid body responding to hypoxia to synthesize dopamine neurotransmitter to heighten ventilation. The association of constitutional susceptibility to HAPE regarding the blunted HVR aspect with polymorphisms of the TH gene was examined.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0012-3692
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
123
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
54-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12527603-Adolescent,
pubmed-meshheading:12527603-Adult,
pubmed-meshheading:12527603-Aged,
pubmed-meshheading:12527603-Altitude,
pubmed-meshheading:12527603-Case-Control Studies,
pubmed-meshheading:12527603-Cross-Sectional Studies,
pubmed-meshheading:12527603-Female,
pubmed-meshheading:12527603-Genetic Predisposition to Disease,
pubmed-meshheading:12527603-Humans,
pubmed-meshheading:12527603-Male,
pubmed-meshheading:12527603-Microsatellite Repeats,
pubmed-meshheading:12527603-Middle Aged,
pubmed-meshheading:12527603-Polymorphism, Genetic,
pubmed-meshheading:12527603-Pulmonary Edema,
pubmed-meshheading:12527603-Tyrosine 3-Monooxygenase
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pubmed:year |
2003
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pubmed:articleTitle |
Polymorphisms of the tyrosine hydroxylase gene in subjects susceptible to high-altitude pulmonary edema.
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pubmed:affiliation |
First Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan. masayuki@hsp.md.shinshu-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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